On the Molecular Diffusion Dynamics Between Subcutaneous Tissue and Microneedles for Wearable Continuous Glucose Monitoring

IF 4.8 Q2 ENGINEERING, BIOMEDICAL

Advanced Nanobiomed Research Pub Date : 2026-06-01 Epub Date: 2026-03-07 DOI:10.1002/anbr.202500302

Wensheng Lin, Binbin Cui, Xuecheng He, Suo Tu, Shilei Dai, Xinran Zhang, Ivo Pang, Xiaonan Chen, Jixiang Zhu, Shiming Zhang

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Abstract

Continuous glucose monitoring (CGM) is a commercially available biochemical sensor for diabetes management. A growing trend in this field is the transition from long needles to microneedles to reduce pain and avoid bleeding. A promising strategy for microneedle-based CGM involves using hydrogel as a filler to bridge the interstitial fluid and externally deployed glucose sensors on the skin surface. However, the glucose diffusion dynamics, critical to the sensing process, remain poorly understood. In this study, we investigate the dynamics of glucose diffusion between subcutaneous tissue and hydrogel-filled microneedles. Specifically, we examine how hydrogel thickness, microneedle size, and glucose concentration influence diffusion. This study provides an experimental reference to the wearable biosensor community researching microneedle-based CGM.

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可穿戴式连续血糖监测中皮下组织与微针之间的分子扩散动力学研究

连续血糖监测（CGM）是一种商用的用于糖尿病管理的生化传感器。该领域的一个日益增长的趋势是从长针过渡到微针，以减少疼痛和避免出血。基于微针的CGM的一个有前途的策略是使用水凝胶作为填充物来桥接组织液和皮肤表面外部部署的葡萄糖传感器。然而，葡萄糖扩散动力学，关键的传感过程，仍然知之甚少。在这项研究中，我们研究了葡萄糖在皮下组织和水凝胶填充的微针之间扩散的动力学。具体来说，我们研究了水凝胶厚度、微针大小和葡萄糖浓度如何影响扩散。本研究为可穿戴生物传感器领域研究基于微针的CGM提供了实验参考。

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来源期刊

Advanced Nanobiomed Research nanomedicine, bioengineering and biomaterials-

CiteScore

5.00

自引率

5.90%

发文量

审稿时长

21 weeks

期刊介绍： Advanced NanoBiomed Research will provide an Open Access home for cutting-edge nanomedicine, bioengineering and biomaterials research aimed at improving human health. The journal will capture a broad spectrum of research from increasingly multi- and interdisciplinary fields of the traditional areas of biomedicine, bioengineering and health-related materials science as well as precision and personalized medicine, drug delivery, and artificial intelligence-driven health science. The scope of Advanced NanoBiomed Research will cover the following key subject areas: ▪ Nanomedicine and nanotechnology, with applications in drug and gene delivery, diagnostics, theranostics, photothermal and photodynamic therapy and multimodal imaging. ▪ Biomaterials, including hydrogels, 2D materials, biopolymers, composites, biodegradable materials, biohybrids and biomimetics (such as artificial cells, exosomes and extracellular vesicles), as well as all organic and inorganic materials for biomedical applications. ▪ Biointerfaces, such as anti-microbial surfaces and coatings, as well as interfaces for cellular engineering, immunoengineering and 3D cell culture. ▪ Biofabrication including (bio)inks and technologies, towards generation of functional tissues and organs. ▪ Tissue engineering and regenerative medicine, including scaffolds and scaffold-free approaches, for bone, ligament, muscle, skin, neural, cardiac tissue engineering and tissue vascularization. ▪ Devices for healthcare applications, disease modelling and treatment, such as diagnostics, lab-on-a-chip, organs-on-a-chip, bioMEMS, bioelectronics, wearables, actuators, soft robotics, and intelligent drug delivery systems. with a strong focus on applications of these fields, from bench-to-bedside, for treatment of all diseases and disorders, such as infectious, autoimmune, cardiovascular and metabolic diseases, neurological disorders and cancer; including pharmacology and toxicology studies.