Very low calorie diet versus conventional energy-restricted diet for weight loss before bariatric surgery. A randomized controlled trial

IF 2.4 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Obesity research & clinical practice Pub Date : 2026-07-01 Epub Date: 2026-05-30 DOI:10.1016/j.orcp.2026.05.009

Sara Schwartz, Marie Kirk, Tina Østergaard Troelsen, Tobias Stadil, Jens Meldgaard Bruun, Bjørn Richelsen, Steen Bønløkke Pedersen, Sigrid Bjerge Gribsholt

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引用次数: 0

Abstract

Background

In Denmark, achieving ≥ 8% preoperative weight loss within 6 months is a requirement for bariatric surgery (BS). This weight loss is difficult for many patients, postponing their surgery.

Objectives

This study aimed to optimize pre-surgical weight loss strategies for patients referred to BS.

Setting

Aarhus University Hospital, Denmark.

Methods

In a prospective study, we evaluated the proportion of patients who underwent BS within 6 months after referral as a marker of successful preoperative weight loss. Furthermore, a randomized controlled trial (RCT) with complete follow-up was performed, comparing very low calorie diet (VLCD) to conventional energy-restricted diet regarding the proportion of patients achieving the mandatory weight loss and undergoing BS within 6 months.

Results

Our prospective study revealed that 67% underwent BS during the entire study period (median time to surgery 8 months), while only 16% underwent BS within 6 months. In the RCT, 65 patients were assigned to either VLCD or conventional diet. The proportion of patients achieving the target weight loss was 94% in the VLCD group vs. 62% in the control group (p < 0.01), and the proportion that underwent BS within 6 months was 86% vs. 38% (p < 0.01), in the VLCD and control group, respectively. VLCD was well tolerated with no adverse effects on surgery time or postoperative complications.

Conclusion

These findings support VLCD as an effective and feasible preoperative intervention to optimize weight loss goals and thereby BS outcomes.

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非常低热量的饮食与传统的能量限制饮食在减肥手术前的减肥效果。一项随机对照试验。

背景：在丹麦，6个月内术前体重减轻≥ 8%是减重手术（BS）的要求。这种减肥对许多患者来说是困难的，推迟了他们的手术。目的：本研究旨在优化BS患者的术前减肥策略。单位：丹麦奥胡斯大学医院。方法：在一项前瞻性研究中，我们评估了转诊后6个月内接受BS的患者比例，作为术前体重减轻成功的标志。此外，我们还进行了一项完全随访的随机对照试验（RCT），比较了极低热量饮食（VLCD）和常规能量限制饮食在6个月内实现强制性减肥并接受BS的患者比例。结果：我们的前瞻性研究显示，67%的患者在整个研究期间（至手术的中位时间为8个月）接受了BS治疗，而只有16%的患者在6个月内接受了BS治疗。在随机对照试验中，65名患者被分配到VLCD或传统饮食组。VLCD组达到减肥目标的患者比例为94%，对照组为62% （p ）。结论：这些发现支持VLCD是一种有效可行的术前干预措施，可以优化减肥目标，从而优化BS结局。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity research & clinical practice 医学-内分泌学与代谢

CiteScore

7.10

自引率

0.00%

发文量

审稿时长

49 days

期刊介绍： The aim of Obesity Research & Clinical Practice (ORCP) is to publish high quality clinical and basic research relating to the epidemiology, mechanism, complications and treatment of obesity and the complication of obesity. Studies relating to the Asia Oceania region are particularly welcome, given the increasing burden of obesity in Asia Pacific, compounded by specific regional population-based and genetic issues, and the devastating personal and economic consequences. The journal aims to expose health care practitioners, clinical researchers, basic scientists, epidemiologists, and public health officials in the region to all areas of obesity research and practice. In addition to original research the ORCP publishes reviews, patient reports, short communications, and letters to the editor (including comments on published papers). The proceedings and abstracts of the Annual Meeting of the Asia Oceania Association for the Study of Obesity is published as a supplement each year.