Desarrollo de cáncer vesical y rectal en los pacientes con cáncer de próstata tratados mediante cirugía o radioterapia: estudio poblacional

IF 1.7 4区医学 Q3 UROLOGY & NEPHROLOGY

Actas urologicas espanolas Pub Date : 2026-06-01 Epub Date: 2026-01-22 DOI:10.1016/j.acuro.2026.501928

P. Martínez Rodríguez, A. Poza Fernández, G. García Fadrique, J. Acedo González, O. Montero Adriá, N. Mateo Cárcel, L. Marzullo Zucchet, F. Gómez Palomo, C. Reig Ruiz

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引用次数: 0

Abstract

Introduction

Radical prostatectomy (RP) and radiotherapy (RT) are the main treatment options for localized and locally advanced (LA) prostate cancer (PCa). While erectile dysfunction and urinary incontinence have been widely studied, there is limited evidence regarding pelvic malignancies and radiation-induced rectal or urinary toxicity.

Materials and methods

This retrospective study involved patients with localized and LA PCa treated exclusively with RP or RT between 2010 and 2019 in our Health Department. A total of 356 patients were included: 138 treated with RP and 218 with RT. Rectal and bladder tumors, as well as urinary and gastrointestinal toxicity variables, were compared using the Chi-square test (Fisher's exact test when expected frequencies were < 5). Multivariate analysis was performed using logistic regression adjusted for clinical variables. Statistical significance was set at P<.05.

Results

Both groups were homogeneous in terms of tumor stage and smoking status. Statistically significant differences were observed between groups in the incidence of pelvic tumors (P=.032), bladder tumors (P=.033), and urinary and gastrointestinal toxicity (P<.001). Patients treated with radiotherapy had an almost 11-fold increased risk of bladder tumors (OR: 10.61; 95% CI: 1.42-224.98).

Conclusions

In our series, patients with localized and LA PCa treated with RT presented a higher incidence of pelvic tumors and urinary/rectal toxicity compared with those treated with RP.

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接受手术或放疗的前列腺癌患者膀胱癌和直肠癌的发展：人群研究

根治性前列腺切除术（RP）和放射治疗（RT）是局部和局部晚期前列腺癌（PCa）的主要治疗选择。虽然勃起功能障碍和尿失禁已被广泛研究，但关于盆腔恶性肿瘤和辐射引起的直肠或尿毒性的证据有限。材料和方法本回顾性研究纳入了2010年至2019年卫生部门仅接受RP或RT治疗的局限性和LA性PCa患者。共纳入356例患者，其中RP治疗138例，rt治疗218例。直肠和膀胱肿瘤以及泌尿和胃肠道毒性变量采用卡方检验（Fisher精确检验，预期频率为<； 5）进行比较。采用经临床变量调整的logistic回归进行多因素分析。差异有统计学意义，p < 0.05。结果两组患者在肿瘤分期和吸烟情况上具有同质性。两组患者盆腔肿瘤发生率（P= 0.032）、膀胱肿瘤发生率（P= 0.033）、泌尿和胃肠道毒性发生率（P= 0.01）差异均有统计学意义。接受放疗的患者发生膀胱肿瘤的风险增加了近11倍（OR: 10.61; 95% CI: 1.42-224.98）。结论在我们的研究中，与RP治疗相比，RT治疗的局限性和LA性前列腺癌患者盆腔肿瘤和尿/直肠毒性的发生率更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Actas urologicas espanolas UROLOGY & NEPHROLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

46 days

期刊介绍： Actas Urológicas Españolas is an international journal dedicated to urological diseases and renal transplant. It has been the official publication of the Spanish Urology Association since 1974 and of the American Urology Confederation since 2008. Its articles cover all aspects related to urology. Actas Urológicas Españolas, governed by the peer review system (double blinded), is published online in Spanish and English. Consequently, manuscripts may be sent in Spanish or English and bidirectional free cost translation will be provided.