Chanakarn Mongkonpruthangkoon, Nitai C Giri, Partha Basu
{"title":"Structure and function of periplasmic nitrate reductase.","authors":"Chanakarn Mongkonpruthangkoon, Nitai C Giri, Partha Basu","doi":"10.1042/BST20250033","DOIUrl":null,"url":null,"abstract":"<p><p>Nitrate reductases are molybdenum cofactor (Moco)-containing enzymes that reduce nitrate to nitrite, the first step in assimilatory and dissimilatory nitrate reduction to ammonia, and in denitrification. Nitrate reductases are divided into four groups; this review will focus on periplasmic nitrate reductase (Nap), discussing the available structures of NapA in the context of other members of the DMSO reductase family. The mechanism and the roles of a specific amino acid residue are also discussed.</p>","PeriodicalId":8841,"journal":{"name":"Biochemical Society transactions","volume":"54 6","pages":"621-631"},"PeriodicalIF":4.4000,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223375/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemical Society transactions","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1042/BST20250033","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Nitrate reductases are molybdenum cofactor (Moco)-containing enzymes that reduce nitrate to nitrite, the first step in assimilatory and dissimilatory nitrate reduction to ammonia, and in denitrification. Nitrate reductases are divided into four groups; this review will focus on periplasmic nitrate reductase (Nap), discussing the available structures of NapA in the context of other members of the DMSO reductase family. The mechanism and the roles of a specific amino acid residue are also discussed.
期刊介绍:
Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences.
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