Statistical analysis of low dose rate mouse experiments with WGS technology and quantitative reproduction of mutation frequency using the whack-a-mole model.
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引用次数: 0
Abstract
We performed whole-genome sequencing (WGS) experiments using mice for several generations under the circumstances of radiation with low dose rates at Tokai University and the Institute for Environmental Sciences (IES) in Japan. The dose rates and total exposed periods were 0.05, 0.15, 1.0, and 20 mGy day-1 for 400, 400, 400, and 300 days, respectively. We performed a statistical analysis of the experimental results on the single-nucleotide variations (SNVs) for each mouse after four generations. The SNVs per generation were unchanged below the dose rate of 1 mGy day-1 within the 95% confidence level errors. The experimental results were reproduced by the Whack-a-Mole (WAM) model with the standard parameters obtained by the Russell mega-mouse experiments.
Annals of the ICRPMedicine-Public Health, Environmental and Occupational Health
CiteScore
4.10
自引率
0.00%
发文量
3
期刊介绍：
The International Commission on Radiological Protection was founded in 1928 to advance for the public benefit the science of radiological protection. The ICRP provides recommendations and guidance on protection against the risks associated with ionising radiation, from artificial sources as widely used in medicine, general industry and nuclear enterprises, and from naturally occurring sources. These reports and recommendations are published six times each year on behalf of the ICRP as the journal Annals of the ICRP. Each issue provides in-depth coverage of a specific subject area.
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