Differential IDH1 Immunohistochemical Expression Across the Pathologically Stratified Spectrum of Intraepithelial and Invasive Laryngeal Squamous Cell Lesions.

Q3 Medicine

Iranian Journal of Pathology Pub Date : 2026-01-01 Epub Date: 2026-02-20 DOI:10.22034/ijp.2025.2067116.3495

Nora Tawhid Abdelfattah El-Zohery, Sara Mohamad Abou-Fandoud, Asmaa Mohamed Saad Zaghloul Attaalla, Abeer Mohammed Amal Mohammed

{"title":"Differential IDH1 Immunohistochemical Expression Across the Pathologically Stratified Spectrum of Intraepithelial and Invasive Laryngeal Squamous Cell Lesions.","authors":"Nora Tawhid Abdelfattah El-Zohery, Sara Mohamad Abou-Fandoud, Asmaa Mohamed Saad Zaghloul Attaalla, Abeer Mohammed Amal Mohammed","doi":"10.22034/ijp.2025.2067116.3495","DOIUrl":null,"url":null,"abstract":"Background & objective: Laryngeal carcinoma is a common head and neck cancer with high morbidity and mortality. This study evaluates IDH1 immunohistochemical expression in pre-invasive and invasive laryngeal squamous cell lesions, its correlation with clinicopathological features, and its prognostic and therapeutic potential.Methods: A retrospective analysis of 65 laryngeal squamous cell lesion cases was conducted using IDH1 immunohistochemistry.Results: IDH1 expression significantly correlated with invasion status (intensity and H-score; p = 0.026, 0.025) and histopathological progression and grade (p = 0.033, 0.036). Two-year DFS and OS were 81.5% and 69%, respectively, with no significant association between survival outcomes and IDH1 H-score (p = 0.851, 0.225).Conclusion: According to our findings, increased IDH1 expression may be associated with features of aggressive tumor behavior and could hold clinical significance in laryngeal squamous cell lesions, potentially serving as a future therapeutic target.","PeriodicalId":38900,"journal":{"name":"Iranian Journal of Pathology","volume":"21 2","pages":"200-215"},"PeriodicalIF":0.0000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13200579/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Pathology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22034/ijp.2025.2067116.3495","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/20 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background & objective: Laryngeal carcinoma is a common head and neck cancer with high morbidity and mortality. This study evaluates IDH1 immunohistochemical expression in pre-invasive and invasive laryngeal squamous cell lesions, its correlation with clinicopathological features, and its prognostic and therapeutic potential.

Methods: A retrospective analysis of 65 laryngeal squamous cell lesion cases was conducted using IDH1 immunohistochemistry.

Results: IDH1 expression significantly correlated with invasion status (intensity and H-score; p = 0.026, 0.025) and histopathological progression and grade (p = 0.033, 0.036). Two-year DFS and OS were 81.5% and 69%, respectively, with no significant association between survival outcomes and IDH1 H-score (p = 0.851, 0.225).

Conclusion: According to our findings, increased IDH1 expression may be associated with features of aggressive tumor behavior and could hold clinical significance in laryngeal squamous cell lesions, potentially serving as a future therapeutic target.

查看原文本刊更多论文

在上皮内和浸润性喉部鳞状细胞病变病理分层谱中IDH1免疫组织化学的差异表达。

背景与目的：喉癌是一种常见的头颈部肿瘤，发病率和死亡率高。本研究评估了侵袭前和侵袭性喉部鳞状细胞病变中IDH1免疫组化表达及其与临床病理特征的相关性，以及其预后和治疗潜力。方法：采用IDH1免疫组化方法对65例喉部鳞状细胞病变病例进行回顾性分析。结果：IDH1表达与侵袭状态（强度、h评分，p = 0.026、0.025）、组织病理进展及分级（p = 0.033、0.036）显著相关。2年DFS和OS分别为81.5%和69%，生存结局与IDH1 H-score无显著相关性（p = 0.851, 0.225）。结论：根据我们的研究结果，IDH1表达升高可能与喉部鳞状细胞病变的侵袭性肿瘤行为特征有关，在喉部鳞状细胞病变中具有临床意义，可能作为未来的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊