Effects of Coenzyme Q10 on Lipid, Glycemic, and Inflammatory Markers in Metabolic Disorders: A Systematic Review and Meta-Analysis.

IF 3.5 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Research Pub Date : 2026-01-01 DOI:10.1155/jdr/5587445

Zhuo Zhang, Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Yufan Song, Mingmin Zhang

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引用次数: 0

Abstract

Background: The rising prevalence of metabolic disorders characterized by dyslipidemia and impaired glucose metabolism has increased interest in effective nutritional supplements. This systematic review and meta-analysis was conducted to evaluate the effects of coenzyme Q10 (CoQ10) on lipid profile, glycemic control, and inflammatory markers.

Methods: PubMed, Web of Science, Scopus, Embase, Cochrane Library, and ClinicalTrials.gov were searched for eligible randomized controlled trials (RCTs). Random-effects models were applied to pool weighted mean differences (WMDs) or standardized mean differences (SMDs) with 95% confidence intervals (CIs).

Results: A total of 64 RCTs (3422 participants) were included. Lipid profile: CoQ10 supplementation significantly improved blood triglyceride (TG, WMD = -5.67 mg/dL; 95% CI: -10.57, -0.77; p = 0.023), total cholesterol (TC, WMD = -4.86 mg/dL; 95% CI: -8.41, -1.30; p = 0.007), high-density lipoprotein cholesterol (HDL-C, WMD = 1.07 mg/dL; 95% CI: 0.22, 1.92; p = 0.013), and low-density lipoprotein cholesterol (LDL-C, WMD = -3.98 mg/dL; 95% CI: -7.00, -0.97; p = 0.010). Glycemic control: CoQ10 significantly reduced hemoglobin A1C (HbA1c, WMD = -0.22%; 95% CI: -0.37, -0.06; p = 0.006), fasting glucose (WMD = -10.07 mg/dL; 95% CI: -14.75, -5.39; p < 0.001), fasting insulin (FINS, WMD = -2.94 μIU/mL; 95% CI: -4.63, -1.25; p = 0.001), and homeostasis model assessment-insulin resistance (HOMA-IR, WMD = -0.82; 95% CI: -1.36, -0.28; p = 0.003). Inflammatory markers: CoQ10 significantly decreased C-reactive protein (CRP, WMD = -0.44 mg/L; 95% CI: -0.79, -0.09; p = 0.013), tumor necrosis factor-α (TNF-α, SMD = -1.01; 95% CI: -1.56, -0.64; p = 0.013), and interleukin-6 (IL-6, SMD = -0.42; 95% CI: -0.79, -0.05; p = 0.027) levels.

Conclusions: CoQ10 supplementation has beneficial effects on lipid metabolism, glycemic control, and inflammation among individuals with metabolic disorders.

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辅酶Q10对代谢紊乱中脂质、血糖和炎症标志物的影响：一项系统综述和荟萃分析

背景：以血脂异常和糖代谢受损为特征的代谢紊乱的患病率不断上升，这增加了人们对有效营养补充剂的兴趣。本系统综述和荟萃分析旨在评估辅酶Q10 （CoQ10）对血脂、血糖控制和炎症标志物的影响。方法：检索PubMed、Web of Science、Scopus、Embase、Cochrane Library和ClinicalTrials.gov，检索符合条件的随机对照试验（RCTs）。随机效应模型应用于池加权平均差（wmd）或标准化平均差（SMDs）， 95%置信区间（ci）。结果：共纳入64项rct（3422名受试者）。脂质谱：补充CoQ10显著改善了血液甘油三酯（TG, WMD = -5.67 mg/dL; 95% CI: -10.57, -0.77; p = 0.023）、总胆固醇（TC, WMD = -4.86 mg/dL; 95% CI: -8.41, -1.30; p = 0.007）、高密度脂蛋白胆固醇（HDL-C, WMD = 1.07 mg/dL; 95% CI: 0.22, 1.92; p = 0.013）和低密度脂蛋白胆固醇（LDL-C, WMD = -3.98 mg/dL; 95% CI: -7.00, -0.97; p = 0.010）。血糖控制：CoQ10显著降低血红蛋白A1C （HbA1c, WMD = -0.22%; 95% CI: -0.37, -0.06; p = 0.006）、空腹血糖（WMD = -10.07 mg/dL; 95% CI: -14.75, -5.39; p < 0.001）、空腹胰岛素（FINS, WMD = -2.94 μIU/mL; 95% CI: -4.63, -1.25; p = 0.001）和稳态模型评估-胰岛素抵抗（HOMA-IR, WMD = -0.82; 95% CI: -1.36, -0.28; p = 0.003）。炎症标志物：CoQ10显著降低c -反应蛋白（CRP, WMD = -0.44 mg/L; 95% CI: -0.79, -0.09; p = 0.013）、肿瘤坏死因子-α (TNF-α, SMD = -1.01; 95% CI: -1.56, -0.64; p = 0.013)和白细胞介素-6 （IL-6, SMD = -0.42; 95% CI: -0.79, -0.05; p = 0.027）水平。结论：补充辅酶q10对代谢紊乱患者的脂质代谢、血糖控制和炎症有有益作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Research ENDOCRINOLOGY & METABOLISM-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

8.40

自引率

2.30%

发文量

152

审稿时长

14 weeks

期刊介绍： Journal of Diabetes Research is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies related to type 1 and type 2 diabetes. The journal welcomes submissions focusing on the epidemiology, etiology, pathogenesis, management, and prevention of diabetes, as well as associated complications, such as diabetic retinopathy, neuropathy and nephropathy.