Maternal blood lead level and its association with birthweight and preterm birth in Adjara, Georgia: An inverse probability of selection weighting analysis of a population-based cohort study

IF 4.3 2区医学 Q1 INFECTIOUS DISEASES

International journal of hygiene and environmental health Pub Date : 2026-06-01 Epub Date: 2026-05-24 DOI:10.1016/j.ijheh.2026.114825

Tinatin Manjavidze , Erik Anda , Ingvild Hersoug Nedberg , Sophio Sikharulidze , Rusudan Shavishvili , Nona Ephadze , Charlotta Rylander

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引用次数: 0

Abstract

Background

Lead exposure poses significant health risks, particularly during pregnancy, as lead affects fetal development. This study aimed to evaluate the association between maternal blood lead levels (BLL), birthweight and preterm birth in Adjara, Georgia.

Methods

Using the nationwide Georgian Birth Registry, we included data on all singleton births in Adjara between 1^stJuly 2021 and December 2023 (n = 13,911) among women who attended antenatal care. Propensity scores and inverse probability of selection (IPS) weights were calculated to balance the characteristics of women with BLL test (n = 7076) and without (n = 6835). IPS-weighed multivariable linear regression model was used to assess the association between maternal BLLs and birthweight, while IPS-weighted multivariable logistic regression models were used to assess associations between maternal BLLs and low birth weight (LBW, <2500 g), and preterm birth (<37 weeks of gestation).

Results

Each 1 μg/dL increase in maternal BLL was associated with a mean reduction of 5g in birthweight (β = −5.02, 95% CI: [-9.05 to −0.99]). No association was observed between BLLs and LBW or preterm birth.

Conclusion

Higher maternal BLLs were associated with lower birthweight. However, no significant relationship was observed between maternal BLLs, LBW and preterm birth.

查看原文本刊更多论文

在格鲁吉亚的Adjara，母亲血铅水平及其与出生体重和早产的关系：一项基于人群的队列研究的逆概率选择加权分析。

背景：铅接触造成重大的健康风险，特别是在怀孕期间，因为铅影响胎儿发育。本研究旨在评估母亲血铅水平（BLL），出生体重和早产之间的关系在阿贾达拉，格鲁吉亚。方法：使用格鲁吉亚全国出生登记处，我们纳入了2021年7月1日至2023年12月期间阿加拉所有接受产前护理的单胎分娩妇女的数据（n = 13,911）。计算倾向得分和逆选择概率（IPS）权重，以平衡接受BLL检验的女性（n = 7076）和未接受BLL检验的女性（n = 6835）的特征。采用ips加权多变量线性回归模型评估产妇BLL与出生体重之间的关系，采用ips加权多变量logistic回归模型评估产妇BLL与低出生体重（LBW）之间的关系，结果：产妇BLL每增加1 μg/dL，出生体重平均减少5g （β = -5.02,95% CI:[-9.05 ~ -0.99]）。没有观察到bll与LBW或早产之间的关联。结论：高bll与低出生体重有关。然而，产妇的身体质量、体重与早产之间没有显著的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of hygiene and environmental health 医学-传染病学

CiteScore

11.50

自引率

5.00%

发文量

151

审稿时长

22 days

期刊介绍： The International Journal of Hygiene and Environmental Health serves as a multidisciplinary forum for original reports on exposure assessment and the reactions to and consequences of human exposure to the biological, chemical, and physical environment. Research reports, short communications, reviews, scientific comments, technical notes, and editorials will be peer-reviewed before acceptance for publication. Priority will be given to articles on epidemiological aspects of environmental toxicology, health risk assessments, susceptible (sub) populations, sanitation and clean water, human biomonitoring, environmental medicine, and public health aspects of exposure-related outcomes.