Suicide Risk Among Transgender Adolescents and Young Adults: A Meta-Analysis of Nearly One Million Participants.

IF 3.4 3区医学 Q2 PSYCHIATRY

International Journal of Methods in Psychiatric Research Pub Date : 2026-06-01 DOI:10.1002/mpr.70077

Noheir Ashraf Ibrahem Fathy Hassan, Eman A Toraih, Menna A Shebl, Amaan Usmani, Uday Atwal, Ayesha Laraib-Ijaz, Helen A O Samuel, Ahmed Ibrahim Eldessouky, Anwar Alhouli, Yusuf Elsawah, Sonnet Sunny, Muaaz Aslam, Jaafer Shah, Yusef Hazimeh, Hani Aiash

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Abstract

Background: Mental health disparities among transgender and gender diverse adolescents and young adults represent a critical public health concern. This meta-analysis examined suicidal risk among transgender youth compared to their cisgender peers.

Methods: Following PRISMA guidelines, we analyzed 29 studies published between 2015-2024, comprising nearly one million participants (957,163; 29,041 transgender and 928,122 cisgender). Random effects models were used to calculate risk ratios (RR) and prevalence estimates for suicidal ideation, planning, attempts, and completion.

Results: Transgender youth showed significantly higher prevalence of suicidal ideation (transmale: 52.2%, transfemale: 49.5% vs. cismale: 18.1%, cisfemale: 22.4%; p < 0.001) and attempts (48.0%-51.3% vs. 18.0%-22.0%; p < 0.001). Risk analyses revealed elevated risks for ideation (RR = 2.38, 95% CI: 1.97-2.88), attempts (RR = 2.85, 95% CI: 1.31-6.21), and completed suicide (RR = 4.80, 95% CI: 2.15-10.74). However, substantial heterogeneity was observed across all suicide outcomes (I² > 90%), indicating that pooled estimates should be interpreted with caution. Publication bias assessment suggested potential overestimation of unadjusted effects, with trim-and-fill adjustment reducing the pooled risk estimate (adjusted RR = 1.25, 95% CI: 1.08-1.45). No significant differences emerged between transmale and transfemale groups (p > 0.05).

Conclusion: Overall, this meta-analysis documents markedly elevated suicidality among transgender adolescents and young adults, while emphasizing the need for cautious interpretation of aggregated effect sizes and further high-quality longitudinal research.

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跨性别青少年和年轻人的自杀风险：近100万参与者的荟萃分析。

背景：跨性别和性别多样化的青少年和年轻人之间的心理健康差异是一个重要的公共卫生问题。这项荟萃分析调查了跨性别青少年与顺性别同龄人的自杀风险。方法：根据PRISMA指南，我们分析了2015-2024年间发表的29项研究，包括近100万参与者（957,163人；29,041名跨性别者和928,122名顺性别者）。随机效应模型用于计算自杀意念、计划、企图和完成的风险比（RR）和患病率估计。结果：跨性别青年的自杀意念患病率明显更高（跨性别青年：52.2%，跨性别青年：49.5%，而顺性别青年：18.1%，顺女性：22.4%，跨性别青年：90%），表明综合估计结果应谨慎解释。发表偏倚评估显示未校正效应可能被高估，校正后的RR = 1.25, 95% CI: 1.08-1.45。跨性别组与跨性别组间差异无统计学意义（p < 0.05）。结论：总体而言，本荟萃分析表明跨性别青少年和年轻人的自杀率明显升高，同时强调需要谨慎解释总体效应大小和进一步的高质量纵向研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Methods in Psychiatric Research 医学-精神病学

CiteScore

5.20

自引率

6.50%

发文量

审稿时长

>12 weeks

期刊介绍： The International Journal of Methods in Psychiatric Research (MPR) publishes high-standard original research of a technical, methodological, experimental and clinical nature, contributing to the theory, methodology, practice and evaluation of mental and behavioural disorders. The journal targets in particular detailed methodological and design papers from major national and international multicentre studies. There is a close working relationship with the US National Institute of Mental Health, the World Health Organisation (WHO) Diagnostic Instruments Committees, as well as several other European and international organisations. MPR aims to publish rapidly articles of highest methodological quality in such areas as epidemiology, biostatistics, generics, psychopharmacology, psychology and the neurosciences. Articles informing about innovative and critical methodological, statistical and clinical issues, including nosology, can be submitted as regular papers and brief reports. Reviews are only occasionally accepted. MPR seeks to monitor, discuss, influence and improve the standards of mental health and behavioral neuroscience research by providing a platform for rapid publication of outstanding contributions. As a quarterly journal MPR is a major source of information and ideas and is an important medium for students, clinicians and researchers in psychiatry, clinical psychology, epidemiology and the allied disciplines in the mental health field.