Anja Reichelt, Sarah Halmer, Emanuel Rotteneder, Anton Staudenherz, Susanne Schubert, Birgit Pfaller
{"title":"Refractory hypokalemic metabolic alkalosis in pregnancy: Interplay of hyperemesis gravidarum and primary hyperparathyroidism.","authors":"Anja Reichelt, Sarah Halmer, Emanuel Rotteneder, Anton Staudenherz, Susanne Schubert, Birgit Pfaller","doi":"10.1177/1753495X261439643","DOIUrl":null,"url":null,"abstract":"<p><p>We report the case of a 32-year-old pregnant woman who presented at 9 weeks of gestation with severe hyperemesis gravidarum (HG) and metabolic disturbances. Biochemical testing revealed hypercalcemia with an inappropriately elevated parathyroid hormone (PTH) level. Subsequent imaging identified a parathyroid adenoma. This case highlights primary hyperparathyroidism as a rare but important differential diagnosis in refractory HG and underscores the diagnostic challenges of interpreting calcium and PTH values during pregnancy.</p>","PeriodicalId":51717,"journal":{"name":"Obstetric Medicine","volume":" ","pages":"1753495X261439643"},"PeriodicalIF":0.7000,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197325/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obstetric Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/1753495X261439643","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
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Abstract
We report the case of a 32-year-old pregnant woman who presented at 9 weeks of gestation with severe hyperemesis gravidarum (HG) and metabolic disturbances. Biochemical testing revealed hypercalcemia with an inappropriately elevated parathyroid hormone (PTH) level. Subsequent imaging identified a parathyroid adenoma. This case highlights primary hyperparathyroidism as a rare but important differential diagnosis in refractory HG and underscores the diagnostic challenges of interpreting calcium and PTH values during pregnancy.
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