Caroline Riben Grundström, Bodil Lund, Nagihan Bostanci, Angelika Silbereisen, Alexandra Pennhag, Ina Schuppe Koistinen, Yinghua Zha, Anastasios Damdimopoulos, Georgios N. Belibasakis, Margareta Hultin
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引用次数: 0
Abstract
Aim
To exploratorily compare the shifts in the salivary microbiome composition after administration of two combined systemic antibiotic regimens used in the surgical treatment of peri-implantitis.
Materials and Methods
A subset of 27 patients treated surgically for peri-implantitis with an adjunctive 7-day course of systemic antibiotics were included (group A, amoxicillin and metronidazole; group B, phenoxymethylpenicillin and metronidazole). Unstimulated saliva was collected before surgery followed by 8 days, 14 days, 6 months and 12 months post surgery. Microbiome profiling was performed using standardised and automated pipelines for DNA extraction and whole genome shotgun sequencing (WGS).
Results
WGS identified 498 species across 194 genera and 16 phyla, with Firmicutes and Actinobacteria being the most abundant. A distinct decrease in alpha diversity was observed on Day 8 relative to baseline across both antibiotic regimens, with signs of richness recovery by Day 14. Alpha and beta diversity analyses showed no statistically significant differences between interventions over the 12-month observation period.
Conclusion
Both adjunctive antibiotic regimens applied in the surgical treatment of peri-implantitis caused comparable ecological disturbances in the salivary microbiome, with no microbiological or clinical evidence supporting the superiority of one regimen over the other.
期刊介绍：
Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology.
The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope.
The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.
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