Diversification in ANME-1 archaea is associated with the presence of highly variable genomic hotspots.

IF 18.1 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Nature Communications Pub Date : 2026-05-25 DOI:10.1038/s41467-026-73573-4

Ying-Li Zhou, Jing-Chun Feng, Rui Lu, Zhe Chen, Paraskevi Mara, Xuanyu Tao, Jinyi Liu, Yongji Huang, Junlin Hu, Jianyun Yao, Virginia P Edgcomb, Andreas Teske, Xiaoxue Wang, Si Zhang

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引用次数: 0

Abstract

Anaerobic methanotrophic (ANME) archaea have been primarily documented by metagenomic analysis of environmental samples. The mechanisms that drive their diversification and speciation are poorly understood. Here we analyse the phylogenomic diversity at the species and strain levels of clade ANME-1 from deep-sea cold seeps, as a model system with a well-studied phylogenetic framework. We reconstruct high-quality circular metagenomic-assembled genomes (cMAGs) and identify highly variable genomic hotspots that distinguish them. Genomic differentiation and diversification in ANME-1 is associated with genes involved in prokaryotic defense systems, transport mechanisms and methane metabolism. In addition, heterologous expression of ANME-1 hicAB operons supports their proposed role as toxin/antitoxin systems, possibly involved in mediating responses to environmental stresses.

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ANME-1古菌的多样化与高度可变的基因组热点的存在有关。

厌氧甲烷营养（ANME）古细菌主要是通过环境样本的宏基因组分析记录的。驱动它们多样化和物种形成的机制尚不清楚。在这里，我们分析了深海冷渗漏进化枝ANME-1在物种和品系水平上的系统发育多样性，作为一个具有充分研究的系统发育框架的模型系统。我们重建了高质量的圆形宏基因组组装基因组（cMAGs），并确定了区分它们的高度可变的基因组热点。ANME-1的基因组分化和多样化与参与原核防御系统、运输机制和甲烷代谢的基因有关。此外，ANME-1 hicAB操纵子的异源表达支持了它们作为毒素/抗毒素系统的作用，可能参与介导对环境应激的反应。

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来源期刊

Nature Communications Biological Science Disciplines-

CiteScore

24.90

自引率

2.40%

发文量

6928

审稿时长

3.7 months

期刊介绍： Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.