3'-sialyllactose inhibits the migration and invasion of LPS-induced B16F10 mouse melanoma cells through inactivation of the NF-_KB signaling pathway.

IF 3 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Glycoconjugate Journal Pub Date : 2026-05-25 DOI:10.1007/s10719-026-10219-z

Hee-Do Kim, Hyunju-Choi, Yu-Chan Chang, Cheorl-Ho Kim

引用次数: 0

Abstract

Malignant melanoma has a high mortality rate and is aggressive. The development, metastasis, and angiogenesis of melanoma have all been connected to toll-like receptor 4 (TLR4). However, signal transduction mediated by TLR4 for accelerating melanoma progression is fully unclear. Because of this, the current research has been carried out to explore drug candidate possibility using 3'-Sialyllactose (3'-SL). We investigated the inhibitory effect of 3'-SL on migration and invasion, which are associated with treatment difficulty and mortality. The suppression of matrix metalloproteinases 9 (MMP-9) expression and activity by 3'-SL in B16F10 murine melanoma cells and concurrently downregulated the MAPK signaling pathway involved in this regulation. Therefore, our results demonstrate that 3'-SL may be a good candidate for the development of therapeutic agents to suppress malignancy associated with metastasis and invasion.

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3'-唾液基乳糖通过抑制NF-KB信号通路的失活，抑制lps诱导的B16F10小鼠黑色素瘤细胞的迁移和侵袭。

恶性黑色素瘤死亡率高，具有侵袭性。黑色素瘤的发展、转移和血管生成都与toll样受体4 （TLR4）有关。然而，TLR4介导的信号转导在加速黑色素瘤进展中的作用尚不清楚。因此，目前的研究是利用3'-唾液基乳糖（3'-SL）来探索候选药物的可能性。我们研究了3'-SL对迁移和侵袭的抑制作用，这与治疗难度和死亡率有关。3′-SL抑制B16F10小鼠黑色素瘤细胞中基质金属蛋白酶9 （matrix metalloproteinases 9, MMP-9）的表达和活性，同时下调参与这一调控的MAPK信号通路。因此，我们的研究结果表明，3'-SL可能是开发抑制恶性肿瘤转移和侵袭相关治疗剂的良好候选者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Glycoconjugate Journal 生物-生化与分子生物学

CiteScore

6.00

自引率

3.30%

发文量

审稿时长

1 months

期刊介绍： Glycoconjugate Journal publishes articles and reviews on all areas concerned with: function, composition, structure, biosynthesis, degradation, interactions, recognition and chemo-enzymatic synthesis of glycoconjugates (glycoproteins, glycolipids, oligosaccharides, polysaccharides and proteoglycans), biochemistry, molecular biology, biotechnology, immunology and cell biology of glycoconjugates, aspects related to disease processes (immunological, inflammatory, arthritic infections, metabolic disorders, malignancy, neurological disorders), structural and functional glycomics, glycoimmunology, glycovaccines, organic synthesis of glycoconjugates and the development of methodologies if biologically relevant, glycosylation changes in disease if focused on either the discovery of a novel disease marker or the improved understanding of some basic pathological mechanism, articles on the effects of toxicological agents (alcohol, tobacco, narcotics, environmental agents) on glycosylation, and the use of glycotherapeutics. Glycoconjugate Journal is the official journal of the International Glycoconjugate Organization, which is responsible for organizing the biennial International Symposia on Glycoconjugates.

3'-sialyllactose inhibits the migration and invasion of LPS-induced B16F10 mouse melanoma cells through inactivation of the NF-KB signaling pathway.

Abstract

3'-sialyllactose inhibits the migration and invasion of LPS-induced B16F10 mouse melanoma cells through inactivation of the NF-_KB signaling pathway.