Relationship between resistin and irisin and atherosclerotic plaque characteristics assessed by optical coherence tomography in patients with coronary artery disease.
Carlos Bobis Álvarez, Marcos Rodríguez Esteban, Nerea Torres González, Julio Hernández Afonso, Delia Almeida González, Antonio Cabrera de León
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引用次数: 0
Abstract
Objective: To analyze the relationship between serum resistin and irisin concentrations and the morphological characteristics of atherosclerotic plaques assessed by optical coherence tomography (OCT) in patients with coronary artery disease.
Methods: A cross-sectional observational study was conducted on 51 patients. In addition to recording comorbidities, irisin and resistin levels were measured using ELISA, and structural plaque parameters (fibroatheroma, neovascularization, calcification, and macrophages) were assessed using OCT. Age- and sex-adjusted regression models were constructed to evaluate the associations of both biomarkers with comorbidities and plaque characteristics. Regression coefficients (β), 95% confidence intervals (95% CI), and p-values were reported.
Results: In the overall patient population, irisin levels were significantly associated with the presence of fibroatheromas (β=8.98 [0.20-17.77]; p=0.045) and neovascularization (β=6.48 [0.47-12.49]; p=0.035). In patients with acute coronary syndrome (ACS), this biomarker showed a stronger association with fibroatheroma (β=11.25 [2.83-19.66]; p=0.010) and neovascularization (β=8.83 [2.38-15.29]; p=0.009). Resistin levels were higher in patients with diabetes mellitus (β=2.41 [0.10-4.72]; p=0.041) were not associated with plaque morphological characteristics.
Conclusions: In patients with coronary artery disease, irisin is associated with fibroatheroma and neovascularization, particularly in the context of ACS. In these patients, resistin is related to diabetes mellitus but not to atherosclerotic plaque features. Both biomarkers may represent different pathophysiological pathways in atherosclerosis.
期刊介绍：
La publicación idónea para acceder tanto a los últimos originales de investigación como a formación médica continuada sobre la arteriosclerosis y su etiología, epidemiología, fisiopatología, diagnóstico y tratamiento. Además, es la publicación oficial de la Sociedad Española de Arteriosclerosis.
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