{"title":"Hardwired and rewired: Tissue macrophages in homeostasis and cancer.","authors":"Hesham Mohei, Donn A Van Deren, Malay Haldar","doi":"10.1093/jleuko/qiag046","DOIUrl":null,"url":null,"abstract":"<p><p>Macrophages are highly heterogeneous innate immune cells that populate virtually all tissues, in which they acquire distinct phenotypes and homeostatic functions shaped by their local environment. Although these cells can arise from either embryonic precursors or circulating monocytes, their ultimate identity reflects an interplay between developmentally encoded transcriptional programs and tissue-derived extrinsic cues. Using selected tissue-resident macrophage subsets as examples, we highlight how environmental signals activate specialized transcriptional modules layered upon a conserved ontogenetic framework to generate the remarkable diversity of macrophage states. We further summarize tissue-specific roles of macrophages and briefly consider how these context-dependent programs influence cancer biology.</p>","PeriodicalId":16186,"journal":{"name":"Journal of Leukocyte Biology","volume":"118 5","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Leukocyte Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jleuko/qiag046","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Macrophages are highly heterogeneous innate immune cells that populate virtually all tissues, in which they acquire distinct phenotypes and homeostatic functions shaped by their local environment. Although these cells can arise from either embryonic precursors or circulating monocytes, their ultimate identity reflects an interplay between developmentally encoded transcriptional programs and tissue-derived extrinsic cues. Using selected tissue-resident macrophage subsets as examples, we highlight how environmental signals activate specialized transcriptional modules layered upon a conserved ontogenetic framework to generate the remarkable diversity of macrophage states. We further summarize tissue-specific roles of macrophages and briefly consider how these context-dependent programs influence cancer biology.
期刊介绍：
JLB is a peer-reviewed, academic journal published by the Society for Leukocyte Biology for its members and the community of immunobiologists. The journal publishes papers devoted to the exploration of the cellular and molecular biology of granulocytes, mononuclear phagocytes, lymphocytes, NK cells, and other cells involved in host physiology and defense/resistance against disease. Since all cells in the body can directly or indirectly contribute to the maintenance of the integrity of the organism and restoration of homeostasis through repair, JLB also considers articles involving epithelial, endothelial, fibroblastic, neural, and other somatic cell types participating in host defense. Studies covering pathophysiology, cell development, differentiation and trafficking; fundamental, translational and clinical immunology, inflammation, extracellular mediators and effector molecules; receptors, signal transduction and genes are considered relevant. Research articles and reviews that provide a novel understanding in any of these fields are given priority as well as technical advances related to leukocyte research methods.
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