Topology-guided multidimensional mechanics-transport-bioactivity mapping and physiological matching of porous bone scaffolds

IF 8.3 1区工程技术 Q1 ENGINEERING, CIVIL

Thin-Walled Structures Pub Date : 2026-05-20 DOI:10.1016/j.tws.2026.115118

Xiaoshuai Yang , Xinyao Yang , Ziwen Guo , Qingxia Li , Changwen Mi , Zhongwei Sun

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引用次数: 0

Abstract

The design of porous bone scaffolds involves balancing the competing demands of mechanical stability and biological functionality. Sufficient stiffness is essential for providing immediate load-bearing capacity after implantation, while long-term bone regeneration requires adequate permeability and flow-induced mechanobiological stimulation. This study systematically assesses the multidimensional performance of 46 representative scaffold architectures, including truss lattices, triply periodic minimal surface (TPMS) structures, and stochastic architectures, within a biologically relevant porosity range of 60% to 80%. Through finite element simulations coupled with Gibson–Ashby scaling analysis, we show that continuous sheet-based topologies exhibit stretching-dominated deformation, significantly enhancing structural efficiency compared to bending-dominated strut and skeletal lattices. Further, three-dimensional elastic tensor analysis reveals substantial spatial anisotropy and off-axis shear vulnerabilities in highly directional lattice systems, whereas continuous sheet and stochastic architectures maintain near-isotropic stiffness distributions and better multiaxial load resistance. Hydrodynamic simulations uncover a critical transport-stimulation trade-off. While orthogonally open lattices maximize intrinsic permeability, their streamlined flow channels generate weak wall shear stress, potentially leading to hydrodynamically under-stimulated regions. In contrast, the bicontinuous curvature of sheet-based architectures modulates local flow patterns, increasing specific surface area and enhancing mechanobiological stimulation. By integrating mechanical, transport, and spatial characteristics, we establish a physiologically motivated tripartite performance map, classifying scaffold architectures into load-bearing prioritized, transport-prioritized, and biomimetic balanced regimes. More importantly, a physiological matching index is introduced to quantitatively assess scaffold suitability for various clinical scenarios. This multidimensional design framework provides a topology-guided foundation for the development of next-generation orthopedic implants tailored to specific physiological needs.

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多孔骨支架的拓扑导向多维力学-运输-生物活性定位与生理匹配

多孔骨支架的设计涉及平衡机械稳定性和生物功能的竞争需求。足够的刚度对于提供植入后的即时承载能力至关重要，而长期的骨再生需要足够的渗透性和血流诱导的机械生物学刺激。本研究系统地评估了46种具有代表性的支架结构的多维性能，包括桁架晶格、三周期最小表面（TPMS）结构和随机结构，其生物学相关孔隙度范围为60%至80%。通过有限元模拟和Gibson-Ashby尺度分析，我们发现基于连续薄片的拓扑结构表现出拉伸主导的变形，与弯曲主导的支柱和骨架晶格相比，显著提高了结构效率。此外，三维弹性张量分析显示，在高度定向的晶格系统中，存在大量的空间各向异性和离轴剪切脆弱性，而连续片状结构和随机结构保持近各向同性的刚度分布，并具有更好的多轴抗载荷能力。流体动力学模拟揭示了一个关键的运输-刺激权衡。虽然正交开放的晶格最大限度地提高了固有渗透率，但其流线型流道产生的壁面剪切应力较弱，可能导致流体动力学欠刺激区域。相比之下，基于薄片结构的双连续曲率调节了局部流动模式，增加了比表面积并增强了机械生物学刺激。通过整合机械、运输和空间特征，我们建立了一个生理驱动的三方性能图，将支架结构分为承重优先、运输优先和仿生平衡体系。更重要的是，引入了生理匹配指标来定量评估支架在各种临床情况下的适用性。这种多维设计框架为下一代骨科植入物的开发提供了拓扑导向的基础，以满足特定的生理需求。

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来源期刊

Thin-Walled Structures 工程技术-工程：土木

CiteScore

9.60

自引率

20.30%

发文量

801

审稿时长

66 days

期刊介绍： Thin-walled structures comprises an important and growing proportion of engineering construction with areas of application becoming increasingly diverse, ranging from aircraft, bridges, ships and oil rigs to storage vessels, industrial buildings and warehouses. Many factors, including cost and weight economy, new materials and processes and the growth of powerful methods of analysis have contributed to this growth, and led to the need for a journal which concentrates specifically on structures in which problems arise due to the thinness of the walls. This field includes cold– formed sections, plate and shell structures, reinforced plastics structures and aluminium structures, and is of importance in many branches of engineering. The primary criterion for consideration of papers in Thin–Walled Structures is that they must be concerned with thin–walled structures or the basic problems inherent in thin–walled structures. Provided this criterion is satisfied no restriction is placed on the type of construction, material or field of application. Papers on theory, experiment, design, etc., are published and it is expected that many papers will contain aspects of all three.