Low-Dose Colchicine for Secondary Prevention in Patients With Chronic Coronary Syndrome: A Multicenter Real-World Study

IF 1.9 3区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Catheterization and Cardiovascular Interventions Pub Date : 2026-08-03 Epub Date: 2026-05-22 DOI:10.1002/ccd.70662

Ecem Gürses, Mustafa Doğduş, Umut Uyan, Ahmet Öz, Shabnam Javadova, Gökçe Nur Durmuş İlhan, Gizem Çabuk, Fatih Sivri, Mehdi Zoghi, İlker Gül

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Abstract

Aims

Chronic coronary syndrome (CCS) remains associated with recurrent ischemic symptoms and impaired quality of life despite contemporary guideline-directed medical therapy. Low-dose colchicine has demonstrated prognostic benefits in randomized trials; however, real-world data regarding its effects on functional capacity and angina-related outcomes are limited.

Methods

This multicenter, real-world observational study included 614 patients with CCS receiving low-dose colchicine therapy for secondary prevention. Functional capacity and angina-related quality of life were assessed before and after colchicine treatment using the Seattle Angina Questionnaire. Changes in daily physical activities, angina frequency, nitroglycerin use, treatment satisfaction, and Canadian Cardiovascular Society (CCS) angina class were evaluated. Clinical outcomes and tolerability, including hospitalization, revascularization, and gastrointestinal adverse effects, were also analyzed. A clinically meaningful improvement was defined as a ≥ 10-point increase in the composite Seattle Angina Questionnaire score.

Results

The mean age of the study population was 68.8 ± 11.5 years, and 70.5% of patients were male. Following colchicine therapy, significant improvements were observed in functional capacity, including walking on level ground, household activities, and carrying heavy objects (all p < 0.001). Angina frequency scores improved, accompanied by reduced nitroglycerin use (p < 0.001). Treatment satisfaction increased and limitations in enjoyment of life decreased significantly (p < 0.001). CCS angina class decreased from 2.61 ± 0.7 to 1.4 ± 0.62 (p < 0.001). A clinically meaningful improvement in SAQ score was observed in 78.7% of patients. During follow-up, hospitalization occurred in 9.0% of patients, revascularization in 4.4%, and gastrointestinal adverse effects were reported in 9.4%.

Conclusions

In a multicenter real-world cohort of patients with chronic coronary syndrome, low-dose colchicine therapy was associated with significant improvements in functional capacity, angina severity, and quality of life, with an acceptable safety profile. The high rate of clinically meaningful patient-reported improvement further supports colchicine as an effective adjunctive therapy for secondary prevention and symptom control in routine clinical practice.

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低剂量秋水仙碱用于慢性冠脉综合征患者的二级预防：一项多中心真实世界研究。

目的：慢性冠状动脉综合征（CCS）仍然与复发性缺血性症状和生活质量受损相关，尽管有当代指南指导的药物治疗。在随机试验中，低剂量秋水仙碱已显示出预后益处；然而，关于其对功能容量和心绞痛相关结果的影响的实际数据有限。方法：这项多中心、真实世界的观察性研究包括614例接受低剂量秋水仙碱治疗的CCS患者。使用西雅图心绞痛问卷评估秋水仙碱治疗前后的功能能力和心绞痛相关生活质量。评估日常体力活动、心绞痛频率、硝酸甘油使用、治疗满意度和加拿大心血管学会（CCS）心绞痛分级的变化。临床结果和耐受性，包括住院、血运重建和胃肠道不良反应，也进行了分析。临床上有意义的改善定义为西雅图心绞痛问卷总分增加≥10分。结果：研究人群的平均年龄为68.8±11.5岁，70.5%为男性。在秋水仙碱治疗后，观察到功能能力的显著改善，包括在平地上行走、家庭活动和搬运重物（均p）。结论：在一项多中心真实世界慢性冠状动脉综合征患者队列研究中，低剂量秋水仙碱治疗与功能能力、心绞痛严重程度和生活质量的显著改善相关，并具有可接受的安全性。患者报告的高临床意义的改善率进一步支持秋水仙碱在常规临床实践中作为二级预防和症状控制的有效辅助治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Catheterization and Cardiovascular Interventions 医学-心血管系统

CiteScore

5.40

自引率

8.70%

发文量

419

审稿时长

2 months

期刊介绍： Catheterization and Cardiovascular Interventions is an international journal covering the broad field of cardiovascular diseases. Subject material includes basic and clinical information that is derived from or related to invasive and interventional coronary or peripheral vascular techniques. The journal focuses on material that will be of immediate practical value to physicians providing patient care in the clinical laboratory setting. To accomplish this, the journal publishes Preliminary Reports and Work In Progress articles that complement the traditional Original Studies, Case Reports, and Comprehensive Reviews. Perspective and insight concerning controversial subjects and evolving technologies are provided regularly through Editorial Commentaries furnished by members of the Editorial Board and other experts. Articles are subject to double-blind peer review and complete editorial evaluation prior to any decision regarding acceptability.