CAMK2 inhibition treats genetic dilated cardiomyopathy in mice

Abstract

Pathogenic variants in RBM20, which encodes a cardiac splicing factor, lead to an aggressive form of dilated cardiomyopathy with a high risk of ventricular arrhythmias. This study shows that genetic or pharmacological inhibition of CAMK2D, one of the RBM20 splicing targets, rescues cardiac dysfunction in mouse models of RBM20.