[Chemical forensic analysis of medicinal tablets discovered during excavations of an ancient burial].

Q4 Medicine

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2026-01-01 DOI:10.17116/sudmed20266903129

A N Prihodko, D Yu Svetlolobov, S V Shigeev, P V Pinchuk, E V Vdovchenkov, N I Shishlina

{"title":"[Chemical forensic analysis of medicinal tablets discovered during excavations of an ancient burial].","authors":"A N Prihodko, D Yu Svetlolobov, S V Shigeev, P V Pinchuk, E V Vdovchenkov, N I Shishlina","doi":"10.17116/sudmed20266903129","DOIUrl":null,"url":null,"abstract":"<p><p>This article presents the results of a chemical forensic analysis of medicinal tablets discovered during the archaeological excavation of an ancient burial site in the Rostov region. The aim of the study was to determine the chemical composition of the tablets using a comprehensive set of analytical methods, including high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-TOF-MS), infrared spectroscopy (FT-IR) and inductively coupled plasma optical emission spectrometry (ICP-OES). An additional objective was to develop a methodological framework for the forensic chemical examination of similar archaeological specimens. Three types of tablets were analyzed. The study outlines sample preparation protocols for each method, analytical conditions, and the results obtained. Morphine, papaverine, and noscapine - alkaloids of the opium poppy (Papaver somniferum and related species) were identified in all examined samples, along with nicotine. Furthermore, the molecular and elemental composition of one tablet was found to correspond to lead oxychloride (mendipite), a naturally occurring mineral. This investigation represents a unique contribution to forensic medical science and archaeology, as no comparable studies have been previously conducted.</p>","PeriodicalId":35704,"journal":{"name":"Sudebno-Meditsinskaya Ekspertisa","volume":"69 3","pages":"29-34"},"PeriodicalIF":0.0000,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sudebno-Meditsinskaya Ekspertisa","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/sudmed20266903129","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

This article presents the results of a chemical forensic analysis of medicinal tablets discovered during the archaeological excavation of an ancient burial site in the Rostov region. The aim of the study was to determine the chemical composition of the tablets using a comprehensive set of analytical methods, including high-performance liquid chromatography coupled with time-of-flight mass spectrometry (HPLC-TOF-MS), infrared spectroscopy (FT-IR) and inductively coupled plasma optical emission spectrometry (ICP-OES). An additional objective was to develop a methodological framework for the forensic chemical examination of similar archaeological specimens. Three types of tablets were analyzed. The study outlines sample preparation protocols for each method, analytical conditions, and the results obtained. Morphine, papaverine, and noscapine - alkaloids of the opium poppy (Papaver somniferum and related species) were identified in all examined samples, along with nicotine. Furthermore, the molecular and elemental composition of one tablet was found to correspond to lead oxychloride (mendipite), a naturally occurring mineral. This investigation represents a unique contribution to forensic medical science and archaeology, as no comparable studies have been previously conducted.

查看原文本刊更多论文

[对古代墓葬发掘中发现的药片进行化学法医分析]。

本文介绍了在罗斯托夫地区古代墓葬遗址考古发掘中发现的药片的化学法医分析结果。采用高效液相色谱-飞行时间质谱法（HPLC-TOF-MS）、红外光谱法（FT-IR）和电感耦合等离子体发射光谱法（ICP-OES）等综合分析方法测定该片剂的化学成分。另一个目标是为类似考古标本的法医化学检查制定一个方法框架。对三种类型的片剂进行了分析。该研究概述了每种方法的样品制备方案、分析条件和获得的结果。吗啡、罂粟碱和诺斯卡平——罂粟（Papaver somniferum及相关物种）的生物碱与尼古丁一起在所有检测样本中被鉴定出来。此外，其中一片的分子和元素组成被发现与氯化氧铅（门地铁矿）相对应，这是一种天然存在的矿物质。这项调查是对法医科学和考古学的独特贡献，因为以前没有进行过类似的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Sudebno-Meditsinskaya Ekspertisa Medicine-Pathology and Forensic Medicine

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： The journal is concerned with the theory and practice of forensic medicine - the problems of thanatology, traumatology, toxicology, serology, forensic obstetrics, forensic dentistry, forensic psychiatry, forensic chemistry, physicotechnical methods of investigation, history of forensic medicine and some problems of criminology and legal laws related to forensic medicine. It publishes original studies by Russian authors, casuistry surveys, abstracts and reviews of Russian and foreign literature, scientific information, reports on scientific conferences.