Chiara Lazzeri, Paolo Antonio Grossi, Manuela Bonizzoli, Davide Ghinolfi, Arianna Trizzino, Giuseppe Feltrin, Adriano Peris
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引用次数: 0
Abstract
Backgrounds: Few data are so far available concerning the infectious risk donor profile in uncontrolled donation after circulatory death (uDCDs), despite the high incidence of infectious complications observed in out-of-hospital cardiac arrest patients.
Methods: We assessed the donor risk profile in utilized uDCD donors consecutively assessed from 2018 to 2024, focusing on the outcome of liver transplant recipients.
Results: Fifty-two consecutive utilized uDCDs were included. In 16 uDCDs, blood cultures were positive. In all these cases, Gram-positive bacteria were observed, mainly cocci (14/16, 88%). These microorganisms were considered contaminants. None of these microorganisms were isolated in recipients. No donor-related infection was detected in the 24 liver transplant recipients.
Conclusions: According to our results, uDCDs show a low risk of infection transmission to the recipients. Nevertheless, a careful and systematic approach to donor evaluation should be pursued and implemented, considering the restricted time frame for assessment and the urgent procedures performed, considering the characteristics of uDCD (comprising the performance of an urgent procedure). Transplant coordinators should promptly report culture positivity in one of the collected samples, thus allowing the timely initiation of antibiotic therapy in the recipients. In uDCD donors, some information on infectious risk may be lacking, considering the limited time and that a urine culture may not be feasible since these donors may be anuric.
期刊介绍：
Transplant Infectious Disease has been established as a forum for presenting the most current information on the prevention and treatment of infection complicating organ and bone marrow transplantation. The point of view of the journal is that infection and allograft rejection (or graft-versus-host disease) are closely intertwined, and that advances in one area will have immediate consequences on the other. The interaction of the transplant recipient with potential microbial invaders, the impact of immunosuppressive strategies on this interaction, and the effects of cytokines, growth factors, and chemokines liberated during the course of infections, rejection, or graft-versus-host disease are central to the interests and mission of this journal.
Transplant Infectious Disease is aimed at disseminating the latest information relevant to the infectious disease complications of transplantation to clinicians and scientists involved in bone marrow, kidney, liver, heart, lung, intestinal, and pancreatic transplantation. The infectious disease consequences and concerns regarding innovative transplant strategies, from novel immunosuppressive agents to xenotransplantation, are very much a concern of this journal. In addition, this journal feels a particular responsibility to inform primary care practitioners in the community, who increasingly are sharing the responsibility for the care of these patients, of the special considerations regarding the prevention and treatment of infection in transplant recipients. As exemplified by the international editorial board, articles are sought throughout the world that address both general issues and those of a more restricted geographic import.
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