Elevated Serum Nardilysin Is Inversely Associated with Cardiovascular Disease in Kidney Transplant Recipients.

IF 2.1 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Kidney & blood pressure research Pub Date : 2026-01-01 Epub Date: 2026-05-21 DOI:10.1159/000552202

Anna Sączek, Krzysztof Batko, Małgorzata Banaszkiewicz, Jolanta Małyszko, Ewa Koc-Żórawska, Marcin Żórawski, Karolina Niezabitowska, Katarzyna Sobczyńska, Przemysław Miarka, Alina Bętkowska-Prokop, Katarzyna Krzanowska, Marcin Krzanowski

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引用次数: 0

Abstract

Background: Kidney transplant recipients (KTRs) suffer from enhanced cardiovascular (CV) and metabolic burden due to interplay between pro-inflammatory and metabolic risk factors. Nardilysin (NRDc) and mitochondrial open reading frame of 12S rRNA-c (MOTS-c) are circulating peptides that represent candidate markers of cardiometabolic pathobiology, though their relevance in KTRs is unknown.

Methods: We measured serum NRDc and MOTS-c concentrations in an observational cohort of 150 patients (118 KTRs and aged-matched controls - 32 patients) using commercial ELISA kits. KTRs were followed for a median of 29.2 (25.3-31.9) months. Relationships with CV and metabolic parameters were assessed using Pearson's correlation and penalized logistic regression. Renal allograft loss with all-cause mortality as competing event was examined using Fine-Gray regression.

Results: Median serum NRDc (1.91 vs. 0.42 ng/mL, p < 0.001) and MOTS-c (178 vs. 142 ng/mL, p = 0.014) were significantly higher in KTRs, as compared with controls. NRDc showed a weak positive linear relationship with BMI (r = 0.21, p = 0.02). After adjusting for age and sex, higher standardized ln-NRDc was independently associated with lower odds of prevalent CV disease (OR 0.59, 95% CI: 0.34-0.97, p = 0.04). This CV disease association was stable after further adjustment for hsIL-6. We did not observe significant associations for MOTS-c and cardiometabolic features. In competing risk analysis, MOTS-c showed a consistent but nonsignificant trend toward lower risk of allograft loss (adj. sHR 0.50, 95% CI: 0.22-1.10, p = 0.08), while NRDc was not associated with allograft loss. Both serum NRDc and MOTS-c markers were not associated with all-cause mortality or follow-up eGFR decline.

Conclusions: Elevated circulating serum NRDc and MOTS-c levels in KTRs may reflect altered metabolic and inflammatory pathways. The inverse association between NRDc and prevalent CV disease warrants further investigation in longitudinal studies with incident CV events.

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肾移植受者血钠溶素升高与心血管疾病呈负相关

背景：由于促炎和代谢危险因素的相互作用，肾移植受者（KTRs）的心血管（CV）和代谢负担加重。Nardilysin （NRDc）和线粒体12S rRNA-c开放阅读框（MOTS-c）是代表心脏代谢病理生物学候选标记的循环肽，尽管它们与KTRs的相关性尚不清楚。方法：我们使用商用ELISA试剂盒检测了150例患者（118例KTRs和32例年龄匹配的对照组）的血清NRDc和MOTS-c浓度。ktr的随访时间中位数为29.2（25.3-31.9）个月。使用Pearson相关和惩罚逻辑回归评估CV和代谢参数之间的关系。同种异体肾移植损失与全因死亡率作为竞争事件使用细灰回归检查。结果：血清NRDc中位数（1.91 vs. 0.42 ng/mL）结论：KTRs循环血清NRDc和MOTS-c水平升高可能反映了代谢和炎症途径的改变。NRDc与流行CV疾病之间的负相关关系值得在CV事件的纵向研究中进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Kidney & blood pressure research 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.