A Comparative Analysis of Cortical Thickness in Female Youth With Non-Suicidal Self-Injury.

IF 2 4区医学 Q3 PSYCHIATRY

Psychiatry Investigation Pub Date : 2026-06-01 Epub Date: 2026-05-22 DOI:10.30773/pi.2025.0268

Hyanghee Jeong, Tae Young Choi, Sujin Bae, Jung Yeon Moon

{"title":"A Comparative Analysis of Cortical Thickness in Female Youth With Non-Suicidal Self-Injury.","authors":"Hyanghee Jeong, Tae Young Choi, Sujin Bae, Jung Yeon Moon","doi":"10.30773/pi.2025.0268","DOIUrl":null,"url":null,"abstract":"Objective: Non-suicidal self-injury (NSSI), prevalent among children and youth, is a risk factor for future suicidal behavior. Nonetheless, the neurobiological mechanisms of NSSI remain under-explored. This study compares the cortical thickness in female youth with NSSI and a healthy control (HC) group using brain magnetic resonance imaging (MRI) and ascertains its associations with relevant factors.Methods: The NSSI group comprised inpatients meeting NSSI diagnostic criteria according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, while the HC group included youth without psychiatric symptoms. Both groups included female adolescents and young adults aged 9-24 years. Clinical data were collected for the NSSI group, and brain MRIs were obtained for both groups. Cortical thickness differences between groups were explored, adjusting for age, and correlations between cortical thickness and clinical variables in the NSSI group were analyzed.Results: Both groups included 32 participants, with no statistically significant difference in average age (NSSI group: mean age 15.47± 3.20 years; HC group: mean age 15.56±4.83 years; p>0.05). Significant intergroup differences in mean cortical thickness were observed in both the left and right hemispheres (both p=0.001). Specifically, the NSSI group exhibited significantly thinner cortical thickness in the right cingulate cortex compared to the healthy HC group (corrected p<0.05). However, correlation analysis between the cortical thickness of the right cingulate cortex and anxiety (State Anxiety Inventory for Children: r=-0.547, p=0.053) (Trait Anxiety Inventory for Children: r=-0.257, p=0.396) and Children's Depression Inventory (r=-0.231, p=0.447) scales in the NSSI group did not reveal statistically significant correlations.Conclusion: The study identified a noteworthy reduction in cortical thickness in the right cingulate cortex in the NSSI group.","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":" ","pages":"829-836"},"PeriodicalIF":2.0000,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13284556/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatry Investigation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.30773/pi.2025.0268","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/5/22 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Non-suicidal self-injury (NSSI), prevalent among children and youth, is a risk factor for future suicidal behavior. Nonetheless, the neurobiological mechanisms of NSSI remain under-explored. This study compares the cortical thickness in female youth with NSSI and a healthy control (HC) group using brain magnetic resonance imaging (MRI) and ascertains its associations with relevant factors.

Methods: The NSSI group comprised inpatients meeting NSSI diagnostic criteria according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, while the HC group included youth without psychiatric symptoms. Both groups included female adolescents and young adults aged 9-24 years. Clinical data were collected for the NSSI group, and brain MRIs were obtained for both groups. Cortical thickness differences between groups were explored, adjusting for age, and correlations between cortical thickness and clinical variables in the NSSI group were analyzed.

Results: Both groups included 32 participants, with no statistically significant difference in average age (NSSI group: mean age 15.47± 3.20 years; HC group: mean age 15.56±4.83 years; p>0.05). Significant intergroup differences in mean cortical thickness were observed in both the left and right hemispheres (both p=0.001). Specifically, the NSSI group exhibited significantly thinner cortical thickness in the right cingulate cortex compared to the healthy HC group (corrected p<0.05). However, correlation analysis between the cortical thickness of the right cingulate cortex and anxiety (State Anxiety Inventory for Children: r=-0.547, p=0.053) (Trait Anxiety Inventory for Children: r=-0.257, p=0.396) and Children's Depression Inventory (r=-0.231, p=0.447) scales in the NSSI group did not reveal statistically significant correlations.

Conclusion: The study identified a noteworthy reduction in cortical thickness in the right cingulate cortex in the NSSI group.

查看原文本刊更多论文

非自杀性自伤女性青少年大脑皮层厚度的比较分析。

目的：非自杀性自伤（NSSI）在儿童和青少年中普遍存在，是未来自杀行为的危险因素。尽管如此，自伤的神经生物学机制仍未得到充分探讨。本研究利用脑磁共振成像技术（MRI）比较了女性青年自伤患者和健康对照组（HC）的皮质厚度，并探讨其与相关因素的关系。方法：自伤组为符合《精神障碍诊断与统计手册》第五版自伤诊断标准的住院患者，HC组为无精神症状的青少年。两组都包括9-24岁的女性青少年和年轻人。收集自伤组的临床资料，并对两组进行脑mri检查。探讨各组间皮质厚度差异，调整年龄，并分析自伤组皮质厚度与临床变量之间的相关性。结果：两组共32例，平均年龄差异无统计学意义（自伤组平均年龄15.47±3.20岁；HC组平均年龄15.56±4.83岁；p < 0.05）。左、右半球平均皮质厚度组间差异显著（p均=0.001）。具体来说，与健康HC组相比，自伤组右侧扣带皮层的皮质厚度明显变薄（修正后）。结论：研究发现，自伤组右侧扣带皮层的皮质厚度明显减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Psychiatry Investigation PSYCHIATRY-

CiteScore

4.10

自引率

3.70%

发文量

105

审稿时长

6-12 weeks

期刊介绍： The Psychiatry Investigation is published on the 25th day of every month in English by the Korean Neuropsychiatric Association (KNPA). The Journal covers the whole range of psychiatry and neuroscience. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and management of neuropsychiatric disorders and symptoms, as well as researches related to cross cultural psychiatry and ethnic issues in psychiatry. The Journal publishes editorials, review articles, original articles, brief reports, viewpoints and correspondences. All research articles are peer reviewed. Contributions are accepted for publication on the condition that their substance has not been published or submitted for publication elsewhere. Authors submitting papers to the Journal (serially or otherwise) with a common theme or using data derived from the same sample (or a subset thereof) must send details of all relevant previous publications and simultaneous submissions. The Journal is not responsible for statements made by contributors. Material in the Journal does not necessarily reflect the views of the Editor or of the KNPA. Manuscripts accepted for publication are copy-edited to improve readability and to ensure conformity with house style.