Non-Pharmacological Inhibition of Aging: Neuroendocrine and Antioxidant Protection of the Liver under the Influence of an Enriched Environment.

Q3 Agricultural and Biological Sciences

Doklady Biological Sciences Pub Date : 2026-06-01 Epub Date: 2026-05-21 DOI:10.1134/S001249662660017X

M V Kondashevskaya, V V Aleksankina, K A Artemyeva, L M Mikhaleva

{"title":"Non-Pharmacological Inhibition of Aging: Neuroendocrine and Antioxidant Protection of the Liver under the Influence of an Enriched Environment.","authors":"M V Kondashevskaya, V V Aleksankina, K A Artemyeva, L M Mikhaleva","doi":"10.1134/S001249662660017X","DOIUrl":null,"url":null,"abstract":"<p><p>The study examined systemic effects of short-term exposure to an enriched environment (EE) on the morphofunctional state of the liver, oxidative-antioxidant balance, and hormonal status in young (3 months) and mature (12 months) males of Wistar rats. In adult control rats, signs of physiological aging were detected: a significant decrease in brain mass ratio, depletion of liver glycogen stores, accumulation of fluorochromes, development of oxidative stress and hormonal imbalance. EE exposure in the regimen of 2 weeks for 10 min/day exerted a pronounced protective effect predominantly in aged animals: brain mass coefficient increased, glycogen content in hepatocytes rose, fluorochrome content in the liver decreased, superoxide dismutase activity increased, and hormonal profile normalized. Young rats showed no significant changes under EE influence, indicating sufficient intrinsic adaptive reserves at this age. The obtained data demonstrate age-dependent modulation of systemic homeostasis under cognitive-sensory stimulation via mechanisms of neuroendocrine regulation and reduction of oxidative damage, opening prospects for developing non-pharmacological strategies to slow aging and maintain functional liver reserve during maturity.</p>","PeriodicalId":11351,"journal":{"name":"Doklady Biological Sciences","volume":" ","pages":"131-138"},"PeriodicalIF":0.0000,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Doklady Biological Sciences","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1134/S001249662660017X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/5/21 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"Agricultural and Biological Sciences","Score":null,"Total":0}

引用次数: 0

Abstract

The study examined systemic effects of short-term exposure to an enriched environment (EE) on the morphofunctional state of the liver, oxidative-antioxidant balance, and hormonal status in young (3 months) and mature (12 months) males of Wistar rats. In adult control rats, signs of physiological aging were detected: a significant decrease in brain mass ratio, depletion of liver glycogen stores, accumulation of fluorochromes, development of oxidative stress and hormonal imbalance. EE exposure in the regimen of 2 weeks for 10 min/day exerted a pronounced protective effect predominantly in aged animals: brain mass coefficient increased, glycogen content in hepatocytes rose, fluorochrome content in the liver decreased, superoxide dismutase activity increased, and hormonal profile normalized. Young rats showed no significant changes under EE influence, indicating sufficient intrinsic adaptive reserves at this age. The obtained data demonstrate age-dependent modulation of systemic homeostasis under cognitive-sensory stimulation via mechanisms of neuroendocrine regulation and reduction of oxidative damage, opening prospects for developing non-pharmacological strategies to slow aging and maintain functional liver reserve during maturity.

查看原文本刊更多论文

非药物抑制衰老：富营养化环境下肝脏的神经内分泌和抗氧化保护。

该研究检测了短期暴露于富营养化环境（EE）对年幼雄性（3个月）和成年雄性（12个月）Wistar大鼠肝脏形态功能状态、氧化-抗氧化平衡和激素状态的全身影响。在成年对照大鼠中，检测到生理性衰老的迹象：脑质量比显著下降，肝糖原储存耗尽，荧光色素积累，氧化应激和激素失衡。2周，10分钟/天的EE暴露方案对老龄动物具有显著的保护作用：脑质量系数增加，肝细胞糖原含量升高，肝脏荧光色素含量降低，超氧化物歧化酶活性增加，激素水平正常化。幼年大鼠在情感表达的影响下没有明显的变化，表明这个年龄有足够的内在适应储备。获得的数据表明，在认知-感觉刺激下，通过神经内分泌调节和减少氧化损伤的机制，系统稳态的年龄依赖性调节，为开发非药物策略来延缓衰老和维持成熟期间的肝脏功能储备开辟了前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Doklady Biological Sciences Agricultural and Biological Sciences-Agricultural and Biological Sciences (all)

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Doklady Biological Sciences is a journal that publishes new research in biological sciences of great significance. Initially the journal was a forum of the Russian Academy of Science and published only best contributions from Russia in the form of short articles. Now the journal welcomes submissions from any country in the English or Russian language. Every manuscript must be recommended by Russian or foreign members of the Russian Academy of Sciences.