Fibromuscular Dysplasia in a Deceased Donor Renal Allograft: Staged Hybrid Endovascular Management and Review of the Literature

Abstract

Background

Fibromuscular dysplasia (FMD) in deceased donor renal allografts is rarely reported in the transplant literature, and there is currently no consensus regarding graft utilization when identified prior to retrieval or optimal operative management following implantation.

Methods

We report a case of deceased donor renal transplantation in which a focal mid–renal artery FMD lesion causing significant stenosis was identified intraoperatively using routine duplex ultrasonography, despite a normal macroscopic appearance of the renal artery on the back table. As the donor had demonstrated normal renal function, a decision was made not to intervene on the lesion at the time of implantation.

Results

Post-operatively, the renal allograft produced urine; however, serum creatinine failed to improve. On post-operative day 3, percutaneous balloon angioplasty of the transplant renal artery stenosis was performed successfully. Renal function normalized promptly following the intervention and remained stable at 12 months of follow-up.

Conclusions

This case highlights several important considerations. A deceased donor kidney with normal donor renal function may still fail to provide adequate recipient function due to previously unsuspected FMD, potentially accounting for unexplained early graft dysfunction in some cases. Routine intraoperative duplex ultrasonography facilitated early detection of the lesion, allowing timely elective intervention. Endovascular repair represents an effective and safe management strategy for FMD in renal allografts when performed in appropriately experienced centers.