Weight Change Between Pregnancies and Mortality Over 50 Years of Follow-Up

IF 4.9 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Obesity Pub Date : 2026-06-26 Epub Date: 2026-05-20 DOI:10.1002/oby.70190

Yajnaseni Chakraborti, Sunni L. Mumford, Edwina H. Yeung, Katherine L. Grantz, Pauline Mendola, James L. Mills, Ellen C. Caniglia, Colleen M. Brensinger, Cuilin Zhang, Enrique F. Schisterman, Stefanie N. Hinkle

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引用次数: 0

Abstract

Objective

This study aimed to evaluate the link between postpartum weight retention (PPWR) and long-term mortality.

Methods

In this secondary analysis of 8165 women with ≥ 2 pregnancies in the Collaborative Perinatal Project (CPP), U.S., 1959–1966, with vital status follow-up through 2016, we used interconception weight change (ICWC) and interpregnancy weight change (IPWC) as proxies of PPWR. ICWC was defined as the difference between self-reported pre-pregnancy weight from the 1st and 2nd CPP pregnancies, while IPWC was the difference between weight recorded at delivery of the 1st and pre-pregnancy weight of the 2nd CPP pregnancies. All-cause and cause-specific mortality models were adjusted for sociodemographic, behavioral, clinical, and pregnancy-related characteristics from the 1st CPP pregnancy.

Results

Compared to women with ICWC > 0 to 1.8 kg (quintile 3), those with ICWC > −1.4 to 0 kg (quintile 2) had a lower risk of all-cause mortality (aHR [95% CI]: 0.85 [0.76–0.96]), with the most notable reduction observed in diabetes-related risk of mortality (aHR [95% CI]: 0.45 [0.23–0.87]). Lower quintiles of IPWC (i.e., greater weight loss) were suggestive of reduced all-cause and cause-specific risk of mortality, though the estimates were not statistically significant.

Conclusions

Minimizing PPWR was linked to reduced mortality risk over 50 years of follow-up.

Abstract Image

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怀孕期间体重变化与50年的随访死亡率。

目的：本研究旨在评估产后体重潴留（PPWR）与长期死亡率之间的关系。方法：对1959-1966年美国合作围产期项目（CPP）中8165例≥2次妊娠的妇女进行二次分析，并随访至2016年，我们使用孕间体重变化（ICWC）和解释性体重变化（IPWC）作为PPWR的替代指标。ICWC定义为第一次和第二次CPP妊娠自我报告的孕前体重的差异，IPWC定义为第一次分娩时记录的体重与第二次CPP妊娠孕前体重的差异。根据首次CPP妊娠的社会人口学、行为、临床和妊娠相关特征调整全因和特定原因死亡率模型。结果：与ICWC体重为0 ~ 1.8 kg（五分位数3）的女性相比，ICWC体重为1 ~ 1.4 ~ 0 kg（五分位数2）的女性全因死亡风险较低（aHR [95% CI]: 0.85[0.76-0.96]），其中与糖尿病相关的死亡风险降低最为显著（aHR [95% CI]: 0.45[0.23-0.87]）。IPWC的较低五分之一（即更大的体重减轻）表明全因和特定原因的死亡风险降低，尽管估计没有统计学意义。结论：在50年的随访中，最小化PPWR与降低死亡风险有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity 医学-内分泌学与代谢

CiteScore

11.70

自引率

1.40%

发文量

261

审稿时长

2-4 weeks

期刊介绍： Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.