{"title":"[HTLV-1-Associated Myelopathy].","authors":"Makoto Nakashima, Yoshihisa Yamano","doi":"10.11477/mf.188160960780050514","DOIUrl":null,"url":null,"abstract":"<p><p>Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) is a neuroimmunological disorder in which the infiltration of HTLV-1-infected T cells into the spinal cord triggers chronic inflammation and neurological damage. HAM predominantly affects the mid-to-lower thoracic cords. Improving long-term outcomes requires accurate assessment of disease activity and timely initiation of therapy. Activity stratification based on cerebrospinal fluid biomarkers is clinically useful.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"78 5","pages":"514-518"},"PeriodicalIF":0.0000,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain and Nerve","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.11477/mf.188160960780050514","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) is a neuroimmunological disorder in which the infiltration of HTLV-1-infected T cells into the spinal cord triggers chronic inflammation and neurological damage. HAM predominantly affects the mid-to-lower thoracic cords. Improving long-term outcomes requires accurate assessment of disease activity and timely initiation of therapy. Activity stratification based on cerebrospinal fluid biomarkers is clinically useful.
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