[Resting-state functional connectivity differences of motor and cognitive impairments in elderly people.]

Abstract

Motor and cognitive impairments in older adults living in long-term care facilities are characterized by high clinical heterogeneity and pose significant challenges for diagnosis and rehabilitation planning. The limited sensitivity of traditional clinical approaches to differentiating the leading component of functional decline limits the possibilities for informed personalization of rehabilitation interventions. The aim of this study was to identify resting-state functional connectivity patterns associated with clinical and rehabilitation profiles (motor, cognitive, and mixed). The cross-sectional study involved 60 residents of a nursing home (mean age 76±11,3 years), stratified into groups based on their predominant motor (n=21), cognitive (n=19), and mixed (n=20) profiles, using comprehensive clinical and functional testing. In total, the student provided most of the information in a state close to that of 164 people within the country; statistical analysis was conducted using power.