Endothelial activation and stress index is independently associated with arteriogenic erectile dysfunction: a cross-sectional study.

IF 2.4 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Sexual Medicine Pub Date : 2026-05-18 eCollection Date: 2026-08-01 DOI:10.1093/sexmed/qfag035

Chuan Xu, Yuyang Zhang, Xu Wu, Guodong Liu, Hao Geng, Dongdong Tang, Xiansheng Zhang

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引用次数: 0

Abstract

Introduction: Arteriogenic erectile dysfunction (AED) is the vascular subtype of erectile dysfunction and is closely linked to endothelial dysfunction. The Endothelial Activation and Stress Index (EASIX), calculated from lactate dehydrogenase (LDH), creatinine, and platelet count, has been recognized as a surrogate marker of endothelial injury in several vascular-related conditions. The aim of this study is to explore the association between EASIX and AED.

Methods: In this cross-sectional study, 193 men were enrolled, including 94 patients diagnosed with AED and 99 controls. Erectile function was assessed using the International Index of Erectile Function-5 (IIEF-5), nocturnal penile tumescence and rigidity, and color duplex Doppler ultrasonography. EASIX was calculated as LDH × creatinine/platelet count. Multivariate logistic regression analysis was performed to evaluate the association between EASIX and AED after adjusting for potential confounders. Receiver operating characteristic (ROC) curve analysis was conducted to assess diagnostic performance.

Results: EASIX levels were significantly higher in the AED group compared to controls (1.13 [0.72-1.55] vs. 0.79 [0.58-1.01], P < .001). In multivariate logistic regression analysis adjusting for age, body mass index, smoking status, metabolic parameters, testosterone levels, and comorbidities, EASIX remained independently associated with AED (OR 1.339, 95% CI 1.239-1.448, P < .001). When analyzed by quartiles, participants in the highest EASIX quartile had a significantly increased likelihood of AED compared with the lowest quartile (P < .001). A significant negative correlation was observed between EASIX and IIEF-5 score (r = -0.291, P = .004). ROC analysis demonstrated that EASIX had moderate diagnostic performance for identifying AED (AUC 0.728, 95% CI 0.656-0.799), which was higher than LDH (AUC 0.680) and creatinine (AUC 0.689).

Conclusion: EASIX was significantly associated with AED and demonstrated moderate diagnostic performance. Prospective studies are warranted to validate its clinical applicability.

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内皮活化和应激指数与动脉源性勃起功能障碍独立相关：一项横断面研究。

动脉源性勃起功能障碍（AED）是勃起功能障碍的血管亚型，与内皮功能障碍密切相关。内皮激活和应激指数（EASIX），由乳酸脱氢酶（LDH）、肌酐和血小板计数计算得出，已被认为是几种血管相关疾病中内皮损伤的替代标志物。本研究旨在探讨EASIX与AED之间的关系。方法：在这项横断面研究中，193名男性入组，包括94名诊断为AED的患者和99名对照组。使用国际勃起功能指数-5 （IIEF-5）、夜间阴茎肿胀和僵硬以及彩色双多普勒超声评估勃起功能。EASIX计算为LDH ×肌酐/血小板计数。在调整潜在混杂因素后，进行多因素logistic回归分析以评估EASIX与AED之间的相关性。采用受试者工作特征（ROC）曲线分析评估诊断效果。结果：AED组EASIX水平明显高于对照组（1.13[0.72-1.55]比0.79 [0.58-1.01],P P P P = 0.004）。ROC分析显示，EASIX对AED的诊断效果中等（AUC 0.728, 95% CI 0.656-0.799），高于LDH （AUC 0.680）和肌酐（AUC 0.689）。结论：EASIX与AED有显著相关性，诊断效果中等。有必要进行前瞻性研究以验证其临床适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sexual Medicine MEDICINE, GENERAL & INTERNAL-

CiteScore

5.40

自引率

0.00%

发文量

103

审稿时长

22 weeks

期刊介绍： Sexual Medicine is an official publication of the International Society for Sexual Medicine, and serves the field as the peer-reviewed, open access journal for rapid dissemination of multidisciplinary clinical and basic research in all areas of global sexual medicine, and particularly acts as a venue for topics of regional or sub-specialty interest. The journal is focused on issues in clinical medicine and epidemiology but also publishes basic science papers with particular relevance to specific populations. Sexual Medicine offers clinicians and researchers a rapid route to publication and the opportunity to publish in a broadly distributed and highly visible global forum. The journal publishes high quality articles from all over the world and actively seeks submissions from countries with expanding sexual medicine communities. Sexual Medicine relies on the same expert panel of editors and reviewers as The Journal of Sexual Medicine and Sexual Medicine Reviews.