Vaccination in individuals with Down syndrome: immune vulnerability, safety, efficacy and opportunities.

IF 7.2 1区医学 Q1 IMMUNOLOGY

NPJ Vaccines Pub Date : 2026-05-19 DOI:10.1038/s41541-026-01489-7

Bernard Khor, Noemi A Spinazzi, Lina R Patel, Erika Chelales, Nicole Baumer, Peter Bulova, Brian Chicoine, Arturo Borzutzky, Hana M El Sahly, Joaquin M Espinosa, Melissa D Gans, Andrew A McCormick, Rebecca Partridge, Eric Rubenstein, Jonathan D Santoro, Cate Speake, Juanita Valdes Camacho, Kishore Vellody

引用次数: 0

Abstract

Although individuals with Down syndrome (DS) remain highly vulnerable to severe infections, vaccination remains underutilized. Here we review, specific to people with DS, the safety and efficacy of vaccination, drivers of susceptibility to infection, and existing and emerging opportunities to improve vaccine response. We find that vaccines are generally safe and immunogenic in individuals with DS, although continued research is essential to improve vaccine efficacy and health outcomes.

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唐氏综合征个体的疫苗接种：免疫脆弱性、安全性、有效性和机会。

尽管唐氏综合症（DS）患者仍然极易受到严重感染，但疫苗接种仍未得到充分利用。在这里，我们回顾了针对退行性椎体滑移患者的疫苗接种的安全性和有效性，感染易感性的驱动因素，以及现有和新出现的改善疫苗反应的机会。我们发现疫苗在退行性椎体滑移患者中通常是安全的和具有免疫原性的，尽管继续研究对提高疫苗效力和健康结果至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Vaccines Immunology and Microbiology-Immunology

CiteScore

11.90

自引率

4.30%

发文量

146

审稿时长

11 weeks

期刊介绍： Online-only and open access, npj Vaccines is dedicated to highlighting the most important scientific advances in vaccine research and development.