Abnormal structural connectivity-functional connectivity coupling beyond the cortex in patients with chronic migraine.

IF 8.7 1区医学 Q1 CLINICAL NEUROLOGY

Journal of Headache and Pain Pub Date : 2026-05-19 DOI:10.1186/s10194-026-02397-w

Yan Li, Yixuan Hu, Chenyu Dai, Fangwang Fu, Yungang Cao, Keyang Chen, Jinming Cheng, Xiaozheng Liu

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引用次数: 0

Abstract

Background: Studies have shown that patients with chronic migraine exhibit abnormalities in structural and functional brain networks. However, the underlying brain mechanisms that govern structural-to-functional connectivity coupling in this population remain unclear.

Methods: Multimodal functional MRI data were collected from 36 patients with chronic migraine without aura, 94 patients with episodic migraine without aura and 51 healthy controls. Spearman's correlation analysis was used to calculate SC-FC coupling. The Kruskal-Wallis test was used to compare differences in SC-FC coupling between the three groups. We also performed a correlation analysis to investigate the associations between SC-FC coupling and clinical variables.

Results: Compared with the healthy control group, patients with episodic migraine exhibited abnormal SC-FC coupling in the right rolandic operculum, left lingual gyrus, left pallidum, and vermis 7. In contrast, patients with chronic migraine exhibited abnormal SC-FC coupling in the left cerebellum 3, vermis 7, and pulvinar nucleus of the thalamus. Patients with chronic migraine exhibited abnormal SC-FC coupling in the left pulvinar nucleus of the thalamus compared with patients with episodic migraine. SC-FC coupling in the left cerebellum 3 of patients with chronic migraine was significantly associated with disability scores (r = -0.3731, p = 0.0250).

Conclusion: Our study identified SC-FC coupling alterations associated with chronic migraine. This suggests that abnormalities in SC-FC coupling in subcortical nuclei and the cerebellum may represent underlying mechanisms of chronic migraine.

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慢性偏头痛患者皮层外结构连接-功能连接耦合异常。

背景：研究表明，慢性偏头痛患者表现出结构和功能脑网络的异常。然而，在这一人群中，控制结构-功能连接耦合的潜在大脑机制仍不清楚。方法：收集36例慢性无先兆偏头痛患者、94例无先兆发作性偏头痛患者和51例健康对照者的多模态功能MRI数据。采用Spearman相关分析计算SC-FC耦合。采用Kruskal-Wallis检验比较三组间SC-FC耦合的差异。我们还进行了相关分析，以调查SC-FC耦合与临床变量之间的关系。结果：与健康对照组相比，发作性偏头痛患者在右侧罗曼盖、左侧舌回、左侧苍白球和蚓部表现出异常的SC-FC偶联。相比之下，慢性偏头痛患者在左小脑3、蚓部7和丘脑枕核中表现出异常的SC-FC偶联。与发作性偏头痛患者相比，慢性偏头痛患者在丘脑左侧枕核中表现出异常的SC-FC偶联。慢性偏头痛患者左小脑SC-FC偶联与残疾评分显著相关（r = -0.3731, p = 0.0250）。结论：我们的研究确定了SC-FC偶联改变与慢性偏头痛相关。这表明皮质下核和小脑中SC-FC偶联的异常可能是慢性偏头痛的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Headache and Pain 医学-临床神经学

CiteScore

11.80

自引率

13.50%

发文量

143

审稿时长

6-12 weeks

期刊介绍： The Journal of Headache and Pain, a peer-reviewed open-access journal published under the BMC brand, a part of Springer Nature, is dedicated to researchers engaged in all facets of headache and related pain syndromes. It encompasses epidemiology, public health, basic science, translational medicine, clinical trials, and real-world data. With a multidisciplinary approach, The Journal of Headache and Pain addresses headache medicine and related pain syndromes across all medical disciplines. It particularly encourages submissions in clinical, translational, and basic science fields, focusing on pain management, genetics, neurology, and internal medicine. The journal publishes research articles, reviews, letters to the Editor, as well as consensus articles and guidelines, aimed at promoting best practices in managing patients with headaches and related pain.