Imaging Sphingosine-1-Phosphate Receptor: A Promising Strategy to Neuroinflammation of Epilepsy.

IF 2.4 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

Molecular Imaging Pub Date : 2026-05-13 eCollection Date: 2026-01-01 DOI:10.1177/15353508261451369

Shuxian Xu, Yanbo Yu, Matthew R Brier, Tammie L S Benzinger, Zhude Tu

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Abstract

Epilepsy is a complex neurological disorder characterized by recurrent, unprovoked seizures. Emerging evidence indicates that the sphingosine-1-phosphate receptor (S1PR) family plays a significant and multifaceted role in the pathological processes underlying epileptogenesis and blood-brain barrier integrity. This review comprehensively explores the intricate role of S1PR signaling in epilepsy, with a particular focus on the integration of neuroimaging findings. In this review, we summarize recent advances in Positron Emission Tomography techniques that offer invaluable insights into S1PR-related pathophysiological changes in the epileptic brain. Furthermore, we discuss the substantial potential of S1PRs as novel therapeutic targets. By integrating these cutting-edge neuroimaging biomarkers with our evolving understanding of the underlying molecular pathways, this review aims to highlight promising new diagnostic tools and innovative treatment strategies for epilepsy.

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鞘氨醇-1-磷酸受体成像：癫痫神经炎症的一种有前途的策略。

癫痫是一种复杂的神经系统疾病，其特点是反复发作，无因发作。新出现的证据表明鞘氨醇-1-磷酸受体（S1PR）家族在癫痫发生和血脑屏障完整性的病理过程中起着重要的多方面作用。这篇综述全面探讨了S1PR信号在癫痫中的复杂作用，特别关注神经影像学结果的整合。在这篇综述中，我们总结了正电子发射断层扫描技术的最新进展，这些技术为癫痫大脑中与s1pr相关的病理生理变化提供了宝贵的见解。此外，我们还讨论了S1PRs作为新型治疗靶点的巨大潜力。通过将这些前沿的神经成像生物标志物与我们对潜在分子途径的不断发展的理解相结合，本综述旨在突出有前途的癫痫新诊断工具和创新治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology

自引率

3.60%

发文量

期刊介绍： Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.