Mandibular Response in Class II Division 1 Growing Subjects: Clear Aligners vs. Rapid Maxillary Expansion Therapy. A Controlled Pilot Study

IF 2.7 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Orthodontics & Craniofacial Research Pub Date : 2026-09-04 Epub Date: 2026-05-16 DOI:10.1111/ocr.70141

De Razza Francesca Chiara, Lugli Letizia, Gazzani Francesca, Lachi Alessio, Pavoni Chiara, Cozza Paola, Lione Roberta

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引用次数: 0

Abstract

Objectives

The present study aimed to evaluate the skeletal and dental changes in two different groups of mixed dentition Class II division 1 patients treated with Clear Aligners and with Rapid Maxillary Expansion and to assess the post-treatment mandibular response in comparison with an untreated control group.

Materials and Method

33 subjects were recruited according to the following inclusion criteria: Caucasian ancestry, early mixed dentition with fully-erupted first permanent molars, bilateral Class II division 1, posterior transverse interarch discrepancy < 5 mm, CSV1–2, no previous orthodontic treatment/congenitally missing or extracted teeth/craniofacial syndromes. The Aligner Group (AG = 13, 6 males, 7 females, 9.2 ± 0.8 years) was treated with Clear Aligners following a standardized sequential expansion protocol “molars move first” without extractions and other auxiliaries than attachments; the RME group (RG = 10 patients, 5 males, 5 females, 9.6 ± 0.7 years) was treated with RME banded on second primary molars; the Control Group (CG = 10, 6 males, 4 females, 9.6 ± 0.9 years) was followed up for 1 year without treatment. Panoramic radiographs and lateral cephalograms were collected pre-treatment (T0) and post-treatment (T1) (T1–T0 = 15.7 ± 1.3 months). The Kruskal–Wallis one-way test was used for the analysis of variance by ranks at T0 (baseline) and for the changes observed between T0 and T1 (p < 0.10).

Results

On the sagittal plane, no significant post-treatment differences in mandibular response were found between the three analysed groups. On the vertical plane, the CA group showed a statistically significant reduction of SN-GoMe when compared to the CG (p = 0.023) and to the RG (p = 0.067).

Conclusions

Clear Aligners and RME did not influence the sagittal skeletal relationship in prepubertal Class II division 1 patients treated during early mixed dentition, compared to the untreated control group. On the vertical plane, patients treated with Clear Aligners showed a statistically significant reduction of SN-GoMe.

Clinical Study Registration Number

Protocol Number E00176-2025

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II类1级生长受试者的下颌反应：清除对准器与快速上颌扩张治疗。一项对照试验研究。

目的：本研究旨在评估两组不同的混合牙列II类1组患者在使用Clear Aligners和快速上颌扩张治疗后骨骼和牙齿的变化，并与未治疗的对照组比较，评估治疗后的下颌反应。材料和方法：根据以下纳入标准招募33名受试者：高加索血统，早期混合牙列并完全出牙的第一恒磨牙，双侧II类1分，后横弓间差异。结果：在矢状面，三个分析组在治疗后的下颌反应没有明显差异。在垂直平面上，CA组的SN-GoMe较CG组（p = 0.023）和RG组（p = 0.067）均有统计学意义的降低。结论：与未治疗的对照组相比，在早期混合牙列治疗的青春期前II类1组患者中，清除对准器和RME对矢状骨关系没有影响。在垂直平面上，使用Clear Aligners治疗的患者SN-GoMe降低具有统计学意义。临床研究注册号：方案号E00176-2025。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Orthodontics & Craniofacial Research 医学-牙科与口腔外科

CiteScore

5.30

自引率

3.20%

发文量

审稿时长

>12 weeks

期刊介绍： Orthodontics & Craniofacial Research - Genes, Growth and Development is published to serve its readers as an international forum for the presentation and critical discussion of issues pertinent to the advancement of the specialty of orthodontics and the evidence-based knowledge of craniofacial growth and development. This forum is based on scientifically supported information, but also includes minority and conflicting opinions. The objective of the journal is to facilitate effective communication between the research community and practicing clinicians. Original papers of high scientific quality that report the findings of clinical trials, clinical epidemiology, and novel therapeutic or diagnostic approaches are appropriate submissions. Similarly, we welcome papers in genetics, developmental biology, syndromology, surgery, speech and hearing, and other biomedical disciplines related to clinical orthodontics and normal and abnormal craniofacial growth and development. In addition to original and basic research, the journal publishes concise reviews, case reports of substantial value, invited essays, letters, and announcements. The journal is published quarterly. The review of submitted papers will be coordinated by the editor and members of the editorial board. It is policy to review manuscripts within 3 to 4 weeks of receipt and to publish within 3 to 6 months of acceptance.