The first metal organic framework phthalocyanine integrated with ZnO using Amaranthus spinosus as an efficient therapeutic candidate for cancer therapy.

IF 5.6 3区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2026-12-01 Epub Date: 2026-05-15 DOI:10.1080/21691401.2026.2668978

Atena Naemi, Fereshteh Ezzati Ghadi

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引用次数: 0

Abstract

The first metal organic framework based on phthalocyanine was synthesized (MOF P). A green synthesis route was employed to fabricate zinc oxide (ZnO) nanoparticles using Amaranthus spinosus extract. The as-synthesized ZnO was subsequently integrated into MOF P, yielding a novel MOF P/ZnO nanocomposite. It was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Brunauer-Emmett-Teller (BET), Fourier transform infra-red spectroscopy (FT-IR), Energy dispersive X-ray analysis (EDAX), elemental analysis, and Ultraviolet-visible (UV-Vis) spectroscopy. This study demonstrates a novel therapeutic platform based on phthalocyanine-integrated metal-organic frameworks (MOFs) and ZnO nanoparticles for targeted and efficient cancer therapy. MTT assay results demonstrated a dose-dependent reduction in cell viability following MOF P/ZnO treatment. Flow cytometry analysis of apoptosis revealed a marked increase in early and late apoptotic cells. Moreover, ROS levels were significantly elevated in treated cells.

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第一个金属有机框架酞菁结合氧化锌利用苋菜作为癌症治疗的有效候选药物。

合成了第一个基于酞菁的金属有机骨架（MOF P）。采用绿色合成路线，以苋菜提取物为原料制备氧化锌纳米颗粒。将合成的ZnO整合到MOF P中，得到了一种新型的MOF P/ZnO纳米复合材料。采用扫描电镜（SEM）、透射电镜（TEM）、布鲁诺尔-埃米特-泰勒（BET）、傅里叶变换红外光谱（FT-IR）、能量色散x射线分析（EDAX）、元素分析和紫外可见（UV-Vis）光谱对其进行了表征。该研究展示了一种基于酞菁-集成金属有机框架（MOFs）和ZnO纳米粒子的靶向和高效癌症治疗的新型治疗平台。MTT分析结果显示，MOF P/ZnO处理后，细胞活力呈剂量依赖性降低。细胞凋亡的流式细胞术分析显示早期和晚期凋亡细胞明显增加。此外，ROS水平在处理细胞中显著升高。

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来源期刊

Artificial Cells, Nanomedicine, and Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ENGINEERING, BIOMEDICAL

CiteScore

10.90

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： Artificial Cells, Nanomedicine and Biotechnology covers the frontiers of interdisciplinary research and application, combining artificial cells, nanotechnology, nanobiotechnology, biotechnology, molecular biology, bioencapsulation, novel carriers, stem cells and tissue engineering. Emphasis is on basic research, applied research, and clinical and industrial applications of the following topics:artificial cellsblood substitutes and oxygen therapeuticsnanotechnology, nanobiotecnology, nanomedicinetissue engineeringstem cellsbioencapsulationmicroencapsulation and nanoencapsulationmicroparticles and nanoparticlesliposomescell therapy and gene therapyenzyme therapydrug delivery systemsbiodegradable and biocompatible polymers for scaffolds and carriersbiosensorsimmobilized enzymes and their usesother biotechnological and nanobiotechnological approachesRapid progress in modern research cannot be carried out in isolation and is based on the combined use of the different novel approaches. The interdisciplinary research involving novel approaches, as discussed above, has revolutionized this field resulting in rapid developments. This journal serves to bring these different, modern and futuristic approaches together for the academic, clinical and industrial communities to allow for even greater developments of this highly interdisciplinary area.