Changes in Time to Diagnosis of HPV + Oropharyngeal Squamous Cell Carcinoma

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2026-10-10 Epub Date: 2026-05-14 DOI:10.1002/hed.70318

Julia Howard, Shaheryar Asad, Danielle M. Gillard, Katherine C. Wai, Mary Jue Xu, Ilya Likhterov, Jonathan R. George, Ivan El-Sayed, William R. Ryan, Patrick K. Ha, Chase Heaton

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引用次数: 0

Abstract

Background

Timely referral to subspecialty care remains critical for expedited work up and treatment of HPV⁺ oropharyngeal carcinoma (OPSCC). It is not known if there have been changes in time to diagnosis as the incidence of this disease rises.

Methods

Retrospective cohort study of 312 patients treated for HPV⁺ OPSCC at a tertiary referral clinic between 2013 and 2022.

Results

There was a significant difference in time to diagnosis based on year of presentation (p < 0.001). More patients presented with early-stage disease (AJCC 7 Stage I or II) over time (p = 0.002). Presenting symptom (p = 0.021) and patient location ≥ 50 miles from our tertiary referral clinic (p = 0.039) also affected time to diagnosis.

Conclusions

Time to diagnosis of HPV⁺ OPSCC changed based on year of presentation, and a higher proportion of patients presented with early-stage disease in more recent years. This may reflect an increased public awareness of HPV⁺ OPSCC and its symptoms.

查看原文本刊更多论文

HPV+口咽鳞状细胞癌诊断时间的变化。

背景：及时转诊到亚专科护理仍然是加快工作和治疗HPV+口咽癌（OPSCC）的关键。目前尚不清楚随着该病发病率的上升，诊断时间是否发生了变化。方法：对2013年至2022年在三级转诊诊所接受HPV+ OPSCC治疗的312例患者进行回顾性队列研究。结论：HPV+ OPSCC的诊断时间随发病年份的变化而变化，近年来出现早期疾病的患者比例较高。这可能反映了公众对HPV+ OPSCC及其症状的认识有所提高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.