Antidiabetic Kidney Disease Benefits of Feeding Rice Starch/Inulin-Enriched Extruded Rice to Diabetes Homozygous Mice

IF 4.2 3区医学 Q2 NUTRITION & DIETETICS

Journal of Nutrition Pub Date : 2026-08-01 Epub Date: 2026-05-13 DOI:10.1016/j.tjnut.2026.101579

Aoyue Sun, Chengbin Sun, Wei Gao, Haiteng Tao, Haibo Zhao, Bin Yu, Zheng Zhang, Pengfei Liu, Bo Cui

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引用次数: 0

Abstract

Background

Diabetic kidney disease (DKD) is the commonest cause of end-stage kidney disease. Supplementation of dietary fiber may have potential benefits for patients with DKD.

Objectives

This study developed a type of functional extruded rice (FER) with rice starch and 10% inulin using twin-screw extrusion, and its beneficial effects on DKD mice were evaluated.

Methods

Mice were divided into control (CON) group (diabetes heterozygous mice fed a normal diet containing extruded rice starch without inulin), model (MOD) group [diabetic MOD, diabetes homozygous mice (db/db) mice fed a normal diet containing extruded rice starch without inulin], FER-fed (RERF) group (db/db mice fed a normal diet containing FER), and metformin-treated group (positive CON, db/db mice treated with metformin and fed a normal diet containing extruded rice starch without inulin).

Results

Physicochemical analysis revealed that resistant starch content was significantly increased by 403.57% in FER compared with extruded rice starch without inulin, which was caused by inulin–starch interactions. Compared with the MOD group, the FER-fed (RERF) group decreased fasting blood glucose by 32.70%, serum creatinine by 50.96%, urea nitrogen by 26.89%, tumor necrosis factor–α by 34.98%, and interleukin-6 by 37.70% (P < 0.05). Histopathology results showed reduced glomerular swelling and colon inflammation in the RERF group compared with the MOD group. Consumption of the FER diet reshaped the profile of gut microbiota, increasing abundances of short-chain fatty acid–producing Anaerostipes and reducing proinflammatory Alistipes. Compared with the MOD group, the RERF group increased acetic acid by 86.88%, propanoic acid by 154.08%, and butanoic acid by 319.56% (P < 0.05).

Conclusions

These findings indicate that FER could be utilized as a food for special dietary use in patients with diabetic kidney, given the dietary fiber–enriched rice's ability to mitigate DKD in an appropriate mouse disease MOD.

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饲喂富含淀粉/菊粉的膨化米对db/db小鼠的抗糖尿病肾病作用

背景：糖尿病肾病（DKD）是终末期肾脏疾病最常见的病因。补充膳食纤维可能对DKD患者有潜在的益处。目的：以米淀粉和10%菊粉为原料，采用双螺杆挤压法制备功能性膨化大米，并评价其对DKD小鼠的有益作用。方法：将小鼠分为CON组（对照组，db/m小鼠饲喂不含菊粉的膨化大米淀粉的正常饲粮）、MOD组（糖尿病模型，db/db小鼠饲喂不含菊粉的膨化大米淀粉的正常饲粮）、RERF组（db/db小鼠饲喂含FER的正常饲粮）和Metf组（阳性对照组，db/db小鼠饲喂二甲双胍处理和不含菊粉的膨化大米淀粉的正常饲粮）。结果：理化分析结果表明，与未添加菊粉的挤出型大米淀粉相比，其抗性淀粉含量显著提高了403.57%，这是菊粉与淀粉相互作用的结果。与MOD组比较，RERF组空腹血糖降低32.70%，血清肌酐降低50.96%，尿素氮降低26.89%，肿瘤坏死因子-α降低34.98%，白细胞介素-6降低37.70% （p < 0.05）。组织病理学结果显示，与MOD组相比，RERF组肾小球肿胀和结肠炎症减轻。FER饮食的摄入改变了肠道菌群的结构，增加了产生短链脂肪酸的厌氧菌的丰度，减少了促炎菌。与MOD组相比，RERF组乙酸提高86.88%，丙酸提高154.08%，丁酸提高319.56% （p < 0.05）。结论：这些发现表明，在适当的小鼠疾病模型中，富含膳食纤维的大米具有减轻DKD的能力，因此ferm可以作为糖尿病肾病患者的特殊饮食使用食品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nutrition 医学-营养学

CiteScore

7.60

自引率

4.80%

发文量

260

审稿时长

39 days

期刊介绍： The Journal of Nutrition (JN/J Nutr) publishes peer-reviewed original research papers covering all aspects of experimental nutrition in humans and other animal species; special articles such as reviews and biographies of prominent nutrition scientists; and issues, opinions, and commentaries on controversial issues in nutrition. Supplements are frequently published to provide extended discussion of topics of special interest.

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AB Triple TOF 6600 mass spectrometer