{"title":"Research Progress of Extracellular Matrix Hardness in Fibrotic Diseases.","authors":"Xiao-Xiao Xue, Shu-Guang Yan, Hai-Liang Wei, Jing-Tao Li, Yong-Xue Zhou","doi":"10.3881/j.issn.1000-503X.16772","DOIUrl":null,"url":null,"abstract":"<p><p>Extracellular matrix is a 3D reticular molecular structure that maintains the structures and functions of cells and provides biomechanical support for cell proliferation and differentiation.The increase in extracellular matrix hardness can destroy the ecological structures and biological functions of normal organs and affect the signal transduction of normal tissue and cells,being a key driver of organ fibrosis.Therefore,reducing the extracellular matrix hardness by inhibiting key signaling pathways and activating fibroblasts can reverse organ fibrosis and promote the steady development of extracellular matrix.This paper expounds the key role of extracellular matrix hardness in fibrosis diseases,providing key therapeutic targets and clinical research directions for ameliorating and reversing organ fibrosis.</p>","PeriodicalId":6919,"journal":{"name":"中国医学科学院学报","volume":"48 2","pages":"355-364"},"PeriodicalIF":0.0000,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中国医学科学院学报","FirstCategoryId":"1087","ListUrlMain":"https://doi.org/10.3881/j.issn.1000-503X.16772","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Extracellular matrix is a 3D reticular molecular structure that maintains the structures and functions of cells and provides biomechanical support for cell proliferation and differentiation.The increase in extracellular matrix hardness can destroy the ecological structures and biological functions of normal organs and affect the signal transduction of normal tissue and cells,being a key driver of organ fibrosis.Therefore,reducing the extracellular matrix hardness by inhibiting key signaling pathways and activating fibroblasts can reverse organ fibrosis and promote the steady development of extracellular matrix.This paper expounds the key role of extracellular matrix hardness in fibrosis diseases,providing key therapeutic targets and clinical research directions for ameliorating and reversing organ fibrosis.
期刊介绍：
Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College.
The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].
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