Role of Brain Insulin Resistance in the Pathogenesis of Alzheimer's Disease.

Q4 Medicine

中国医学科学院学报 Pub Date : 2026-04-01 DOI:10.3881/j.issn.1000-503X.16614

Xiao-Tong Zhang, Sang-Sang Chen, Yue-Wen Liu, Hao-Ran Huang, Ying Yu

引用次数: 0

Abstract

Alzheimer's disease (AD) is the most common type of dementia,in which brain insulin resistance (BIR) plays a key role.BIR affects the response of brain cells to insulin and is associated with cognitive decline and pathological features of AD.This study explores the role of BIR in the pathogenesis of AD and evaluates potential treatment strategies,aiming to provide new directions for the prevention and treatment of AD.

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脑胰岛素抵抗在阿尔茨海默病发病机制中的作用

阿尔茨海默病（AD）是最常见的痴呆类型，其中脑胰岛素抵抗（BIR）起着关键作用。BIR影响脑细胞对胰岛素的反应，并与AD的认知能力下降和病理特征有关。本研究旨在探讨BIR在AD发病机制中的作用，并评估潜在的治疗策略，旨在为AD的预防和治疗提供新的方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中国医学科学院学报 Medicine-Medicine (all)

CiteScore

0.60

自引率

0.00%

发文量

6813

期刊介绍： Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College. The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].