A bioactive sea buckthorn flavonoid-based nanocomposite dressing with on-demand release for managing diabetic wounds

IF 9.4 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Nano Research Pub Date : 2025-11-04 DOI:10.26599/nr.2025.94908230

Xinyu Zhong, Yuhang Feng, Dongwei Xin, Wenya Liu, Ruixi Gan, Huihui Meng, Qi Zheng, Xiaoyu Wang, Junsong Wang, Di Xu

{"title":"A bioactive sea buckthorn flavonoid-based nanocomposite dressing with on-demand release for managing diabetic wounds","authors":"Xinyu Zhong, Yuhang Feng, Dongwei Xin, Wenya Liu, Ruixi Gan, Huihui Meng, Qi Zheng, Xiaoyu Wang, Junsong Wang, Di Xu","doi":"10.26599/nr.2025.94908230","DOIUrl":null,"url":null,"abstract":"In the field of diabetic wound dressings, currently available microwave-responsive materials often suffer from limitations such as slow response and simplistic release profiles, which hinder precise control and effective treatment. This study introduces a innovatively designed PSTZ nanocomposite—comprising PVA, SA, TFH, and ZIF-67—as a novel intelligent wound dressing capable of rapid microwave activation. The system efficiently encapsulates total flavonoids within a ZIF-67 metal–organic framework to form TFH-ZIF67 nanoparticles, which are incorporated into a polyvinyl alcohol/sodium alginate (PVA/SA) hydrogel matrix via electrospinning. Upon microwave stimulation, the ZIF-67 component enables instantaneous thermal response and accelerated drug release, achieving a temperature rise of 50°C in just 15 seconds and enhancing drug release rate by 32.7% compared to room temperature conditions. Beyond conventional dressings, PSTZ demonstrates unique capability to intelligently regulate key molecular pathways involved in wound healing, offering a transformative strategy for treating diabetic wounds.","PeriodicalId":713,"journal":{"name":"Nano Research","volume":"19 5","pages":"94908230-94908230"},"PeriodicalIF":9.4000,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nano Research","FirstCategoryId":"0","ListUrlMain":"https://doi.org/10.26599/nr.2025.94908230","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

Abstract

In the field of diabetic wound dressings, currently available microwave-responsive materials often suffer from limitations such as slow response and simplistic release profiles, which hinder precise control and effective treatment. This study introduces a innovatively designed PSTZ nanocomposite—comprising PVA, SA, TFH, and ZIF-67—as a novel intelligent wound dressing capable of rapid microwave activation. The system efficiently encapsulates total flavonoids within a ZIF-67 metal–organic framework to form TFH-ZIF67 nanoparticles, which are incorporated into a polyvinyl alcohol/sodium alginate (PVA/SA) hydrogel matrix via electrospinning. Upon microwave stimulation, the ZIF-67 component enables instantaneous thermal response and accelerated drug release, achieving a temperature rise of 50°C in just 15 seconds and enhancing drug release rate by 32.7% compared to room temperature conditions. Beyond conventional dressings, PSTZ demonstrates unique capability to intelligently regulate key molecular pathways involved in wound healing, offering a transformative strategy for treating diabetic wounds.

查看原文本刊更多论文

一种生物活性沙棘类黄酮纳米复合敷料，可按需释放，用于管理糖尿病伤口

在糖尿病伤口敷料领域，目前可用的微波响应材料往往存在反应慢、释放谱简单等局限性，阻碍了精确控制和有效治疗。本研究介绍了一种创新设计的PSTZ纳米复合材料——包括PVA、SA、TFH和zif -67——作为一种新型的智能伤口敷料，能够快速微波激活。该系统有效地将总黄酮封装在ZIF-67金属有机框架内，形成TFH-ZIF67纳米颗粒，通过静电纺丝将其结合到聚乙烯醇/海藻酸钠（PVA/SA）水凝胶基质中。在微波刺激下，ZIF-67组件可以实现瞬时热响应和加速药物释放，在15秒内实现50°C的温度升高，与室温条件相比，药物释放率提高了32.7%。除了传统的敷料，PSTZ展示了智能调节伤口愈合关键分子途径的独特能力，为治疗糖尿病伤口提供了一种变革性策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nano Research 化学-材料科学：综合

CiteScore

14.30

自引率

11.10%

发文量

2574

审稿时长

1.7 months

期刊介绍： Nano Research is a peer-reviewed, international and interdisciplinary research journal that focuses on all aspects of nanoscience and nanotechnology. It solicits submissions in various topical areas, from basic aspects of nanoscale materials to practical applications. The journal publishes articles on synthesis, characterization, and manipulation of nanomaterials; nanoscale physics, electrical transport, and quantum physics; scanning probe microscopy and spectroscopy; nanofluidics; nanosensors; nanoelectronics and molecular electronics; nano-optics, nano-optoelectronics, and nano-photonics; nanomagnetics; nanobiotechnology and nanomedicine; and nanoscale modeling and simulations. Nano Research offers readers a combination of authoritative and comprehensive Reviews, original cutting-edge research in Communication and Full Paper formats. The journal also prioritizes rapid review to ensure prompt publication.