Modulation of stem cells from apical papilla using direct current electric fields: A pathway toward translational dentin regeneration

Q2 Dentistry

Journal of dental hygiene : JDH / American Dental Hygienists'' Association Pub Date : 2025-04-01 DOI:10.1016/j.tdr.2025.100019

Xiaolin Li, Yu Gu, Jingyi Li, Yan Wang, Qian Liu, Lihong Qiu, Alastair J. Sloan, Fa‐Ming Chen, Xu Chen, Bing Song

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Abstract

Dentin is produced by odontoblasts, which originate from mesenchymal cells in the dental papilla. Although numerous studies have explored the molecular switches involved in the differentiation of stem cells from apical papilla (SCAP), little is known about the involvement of electric signals in this process. Recent advances indicate that injured dentin generates an electric current. Therefore, it is essential to evaluate whether the extracellular electrical environment surrounding SCAP in the damaged root can promote tissue repair and regeneration. This study aims to investigate the regulatory effects of direct current electric fields (DCEFs) on SCAP, with the potential to contribute to innovative strategies for tooth regeneration. These strategies include the construction of in vitro models for mechanistic studies, the design of piezoelectric hydrogels for pulp regeneration, the development of novel dental pharmaceuticals, and the development of new clinical treatment techniques. • SCAP demonstrated anodal electrotaxis in DCEFs. • DCEFs influenced the proliferation and early odontogenic differentiation abilities of SCAP.

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直流电场对根尖乳头干细胞的调节：一种导向牙本质再生的途径

牙本质是由成牙细胞产生的，成牙细胞起源于牙乳头的间充质细胞。尽管许多研究探索了干细胞从根尖乳头（SCAP）分化的分子开关，但对电信号在这一过程中的作用知之甚少。最近的进展表明，受伤的牙本质会产生电流。因此，有必要评估受损根SCAP周围的细胞外电环境是否能促进组织修复和再生。本研究旨在探讨直流电场（DCEFs）对SCAP的调节作用，以期为牙齿再生的创新策略做出贡献。这些策略包括构建体外机制研究模型、设计用于牙髓再生的压电水凝胶、开发新型牙科药物以及开发新的临床治疗技术。•SCAP显示DCEFs的阳极电趋向性。•DCEFs影响SCAP的增殖和早期成牙分化能力。

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来源期刊

Journal of dental hygiene : JDH / American Dental Hygienists'' Association Medicine-Medicine (all)

CiteScore

1.50

自引率

0.00%

发文量

期刊介绍： The Journal of Dental Hygiene is the refereed, scientific publication of the American Dental Hygienists’ Association. It promotes the publication of original research related to the practice and education of dental hygiene. It supports the development and dissemination of a dental hygiene body of knowledge through scientific inquiry in basic, applied, and clinical research.