Effect of Flexible Plasma Pad on HaCaT Cells and Bacteria

IF 3.2 3区物理与天体物理 Q2 PHYSICS, APPLIED

Plasma Processes and Polymers Pub Date : 2025-02-04 DOI:10.1002/ppap.202400244

Chenglong Ding, Zhidan Sun, Y. Andrew Wang, Han Zhou, Qing Huang, Wencheng Song

引用次数: 1

Abstract

ABSTRACT Dielectric barrier discharge (DBD) is a method that promotes wound healing. This study designed a flexible plasma pad with a polyimide film as the dielectric layer and patterned copper foil as the ground electrode. The flexible plasma pad was used to treat normal skin cells and bacteria at the wound site. Cell viability, intracellular and extracellular active substances, and Western blot analysis indicated that LTP can activate the PI3K/AKT/mTOR signaling pathway, decrease E‐Cadherin expression, and promote HaCaT cell proliferation. It exhibits antibacterial activity against Staphylococcus aureus and Escherichia coli . The results of this study suggest that this plasma pad is an efficient device for treating wounds and bacterial infections.

查看原文本刊更多论文

柔性血浆垫对HaCaT细胞及细菌的影响

介质阻挡放电（DBD）是一种促进伤口愈合的方法。本研究设计了一种以聚酰亚胺薄膜为介电层，图案铜箔为地电极的柔性等离子体衬垫。柔性血浆垫用于治疗伤口部位的正常皮肤细胞和细菌。细胞活力、细胞内外活性物质和Western blot分析表明，LTP可以激活PI3K/AKT/mTOR信号通路，降低E‐Cadherin表达，促进HaCaT细胞增殖。对金黄色葡萄球菌和大肠杆菌具有抗菌活性。这项研究的结果表明，这种等离子垫是治疗伤口和细菌感染的有效装置。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Plasma Processes and Polymers 物理-高分子科学

CiteScore

6.60

自引率

11.40%

发文量

150

审稿时长

3 months

期刊介绍： Plasma Processes & Polymers focuses on the interdisciplinary field of low temperature plasma science, covering both experimental and theoretical aspects of fundamental and applied research in materials science, physics, chemistry and engineering in the area of plasma sources and plasma-based treatments.