Study on the bactericidal effect and its mechanism of nitrox surface discharge plasma-treated hydrogel

Abstract

Abstract As novel carriers of plasma-generated reactive oxygen and nitrogen species (RONS), plasma-treated hydrogels (PTHs) have broad biomedical applications. Regulating the key reactive species in PTHs is crucial for optimal biomedical effects. This study focuses on how N 2 /O 2 ratios in discharge gas of surface dielectric barrier discharge affect RONS generation and its correlation with the bactericidal effect plasma-treated AVC hydrogel (PTH AVC ). It was found that PTH AVC achieved the best bactericidal effect and contained the highest concentration of ONOO − aq /ONOOH aq when the O 2 content was 70%, indicating that ONOO − aq /ONOOH aq may play a key role in the bactericidal effect of PTH AVC . This study provides a new strategy to regulate the biological activity of PTH AVC and valuable insights into its bactericidal mechanism.