Dithiolane-based antibody eyedrops for noninvasive treatment of corneal neovascularization

IF 9.4 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Nano Research Pub Date : 2025-11-19 DOI:10.26599/nr.2025.94907904

Jie Zhou, Shuang Lin, Biting Zhou, Qimei He, Wenjun Xie, Dongna Xiao, Yaduan Wang, Xin Zhang, Rui Liu, Qian Yang, Gang Qin, Yihua Zhu, Nanwen Zhang, Juhua Yang, Xiaole Chen

引用次数: 0

Abstract

This study screened an anti-VEGF single-domain antibody (sdVE01) and designed four dithiolane molecules (DM) to construct the dithiolane-based antibody eyedrops, which may be an attractive non-invasive strategy for treating ocular neovascularization disease.

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以二硫代烷为基础的抗体滴眼液无创治疗角膜新生血管

本研究筛选了一种抗vegf单域抗体（sdVE01），设计了四种二硫代烷分子（DM），构建了基于二硫代烷的抗体滴眼液，这可能是治疗眼部新生血管疾病的一种有吸引力的无创策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nano Research 化学-材料科学：综合

CiteScore

14.30

自引率

11.10%

发文量

2574

审稿时长

1.7 months

期刊介绍： Nano Research is a peer-reviewed, international and interdisciplinary research journal that focuses on all aspects of nanoscience and nanotechnology. It solicits submissions in various topical areas, from basic aspects of nanoscale materials to practical applications. The journal publishes articles on synthesis, characterization, and manipulation of nanomaterials; nanoscale physics, electrical transport, and quantum physics; scanning probe microscopy and spectroscopy; nanofluidics; nanosensors; nanoelectronics and molecular electronics; nano-optics, nano-optoelectronics, and nano-photonics; nanomagnetics; nanobiotechnology and nanomedicine; and nanoscale modeling and simulations. Nano Research offers readers a combination of authoritative and comprehensive Reviews, original cutting-edge research in Communication and Full Paper formats. The journal also prioritizes rapid review to ensure prompt publication.