Effects of Compound Jinji Granules on Sexual Behavior in a Rat Model of Premature Ejaculation

Abstract

Background: Premature ejaculation (PE) is a common male sexual dysfunction, with current treatments showing limited efficacy. Exploring new medications to improve ejaculation latency offers a promising path for more effective therapies. Methods: This study was conducted to examine the effects of compound Jinji granules (CJG) on the ejaculatory behavior of a rat model. The study included a blank group, a model group, a CJG formula group, and a positive control group, with 10 rats in each group. The model rats were selected based on the continuum principle of ejaculation. The CJG group was gavaged with the CJG formula, while the positive control group was intraperitoneally injected with Cligosiban for four weeks. The sexual behavior of the rats, including indicators such as ejaculation latency (EL), was observed, and the data were statistically analyzed using SPSS 25.0 software. Results: The model group exhibited significantly reduced intromission latency (IL), ejaculation frequency (EF), and mount frequency (MF) compared to the blank group. Compared to the model group, CJG significantly prolonged IL, EL, and MF ( P < 0.01), extended IF ( P < 0.05), and reduced EF ( P < 0.05). There were no significant differences between the CJG group and the positive control group (Cligosiban) in terms of IL, EL, MF, IF, and EF. Conclusion: CJG significantly improved sexual behavior in the PE rat model, extending EL and reducing the frequency of ejaculation. These results suggest that CJG may offer a promising therapeutic option for treating PE.