Artificial Heart Valve Scaffold Based on Electrospun PCL/PU Three-Layer Composite Fibers

Q1 Mathematics

Applied Sciences Pub Date : 2024-12-21 DOI:10.3390/app142412001

Xu Gao, Zhong Liu, Zhiwei Zhang, Yuan Gao, Jun Zhang, Yunze Long

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引用次数: 3

Abstract

Abnormal heart valve function is a major cause of heart disease and is often associated with high rates of morbidity and mortality from heart disease. Focusing on the field of valve replacement, tissue-engineered heart valves are becoming popular and attracting more attention. In this work, an artificial heart valve scaffold based on polycaprolactone/polyurethane (PCL/PU) three-layer composite fibers was prepared by 3D printing and electrospinning, including an inner PCL layer, a middle PCL/PU layer, and an outer PCL layer. The obtained valve scaffold had strong circumferential mechanical properties when PCL/PU = 1:2, and its elastic modulus was 14.7 MPa, similar to that of natural valve. The heart valve scaffold had good cytocompatibility, and the final cell survival rate was 99.8% after 14 days of cell culture. The layered structure makes the artificial heart valve more similar to the natural structure of the mammalian heart, which is conducive to cell proliferation and differentiation, and provides a reference solution for interventional treatment of heart valves.

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基于静电纺PCL/PU三层复合纤维的人工心脏瓣膜支架

心脏瓣膜功能异常是心脏病的主要原因，通常与心脏病的高发病率和死亡率有关。在瓣膜置换术领域，组织工程心脏瓣膜的应用越来越广泛，越来越受到关注。本研究采用3D打印和静电纺丝技术制备了基于聚己内酯/聚氨酯（PCL/PU）三层复合纤维的人工心脏瓣膜支架，包括内层PCL、中间层PCL/PU和外层PCL。所制备的瓣膜支架在PCL/PU = 1:2时具有较强的周向力学性能，弹性模量为14.7 MPa，与天然瓣膜相似。该心脏瓣膜支架具有良好的细胞相容性，细胞培养14 d后，最终细胞存活率为99.8%。分层结构使人工心脏瓣膜更接近哺乳动物心脏的天然结构，有利于细胞增殖和分化，为心脏瓣膜介入治疗提供参考解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Sciences Mathematics-Applied Mathematics

CiteScore

6.40

自引率

0.00%

发文量

审稿时长

11 weeks

期刊介绍： APPS is an international journal. APPS covers a wide spectrum of pure and applied mathematics in science and technology, promoting especially papers presented at Carpato-Balkan meetings. The Editorial Board of APPS takes a very active role in selecting and refereeing papers, ensuring the best quality of contemporary mathematics and its applications. APPS is abstracted in Zentralblatt für Mathematik. The APPS journal uses Double blind peer review.