Acrylic resin-coated rhodamine-6G/isorhamnetin/nido-carborane fluorescent complexes: Photophysical properties, drug release, and tumor cell imaging studies

IF 3.3 3区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Journal of King Saud University - Science Pub Date : 2025-05-21 DOI:10.25259/jksus_322_2024

Jian‐Peng Hu, Bo Teng, Yuanye Wan, Zhipeng Xu, Guofan Jin

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引用次数: 0

Abstract

Biocompatibility and solubility problems of the isorhamnetin- nido -carborane complex were resolved by creating four fluorescent complexes using a one-pot method: L100-55@rhodamine-6G/isorhamnetin/nido-carborane (RIC-1), EPO@rhodamine-6G/isorhamnetin/nido-carborane (RIC-2), RS@rhodamine-6G/isorhamnetin/nido-carborane (RIC-3), and RL@rhodamine-6G/isorhamnetin/nido-carborane (RIC-4). When it came to UV absorption stability, RIC-1 was unique among them. Transmission electron microscopy (TEM) analysis shows that RIC-1 forms a flocculent, network-like structure in the acrylic matrix with uniform dispersion, indicating a stable complex. Cytotoxicity and therapeutic potential were evaluated using CCK8 and cell uptake assays. With inhibition rates of 49-56% and 55-62%, respectively, RIC-1 showed low cytotoxicity and strong anti-tumor efficacy, specifically targeting PC3 and HeLa tumor cells. This study emphasizes the potential of this fluorescent complex, in particular RIC-1, for targeted cancer therapy as well as for better tumor imaging and therapeutic applications.

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丙烯酸树脂包被罗丹明- 6g /异鼠李素/nido-碳硼烷荧光复合物：光物理性质、药物释放和肿瘤细胞成像研究

采用一罐法制得四种荧光配合物：L100-55@rhodamine-6G/异鼠李素/nido-碳硼烷（RIC-1）、EPO@rhodamine-6G/异鼠李素/nido-碳硼烷（RIC-2）、RS@rhodamine-6G/异鼠李素/nido-碳硼烷（RIC-3）和RL@rhodamine-6G/异鼠李素/nido-碳硼烷（RIC-4），解决了异鼠李素- nido-碳硼烷配合物的生物相容性和溶解度问题。在紫外线吸收稳定性方面，RIC-1在其中是独一无二的。透射电镜（TEM）分析表明，RIC-1在丙烯酸基体中形成絮状、网状结构，分散均匀，是一种稳定的配合物。使用CCK8和细胞摄取法评估细胞毒性和治疗潜力。RIC-1的抑制率分别为49-56%和55-62%，具有较低的细胞毒性和较强的抗肿瘤功效，特异性靶向PC3和HeLa肿瘤细胞。这项研究强调了这种荧光复合物，特别是RIC-1，在靶向癌症治疗以及更好的肿瘤成像和治疗应用方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of King Saud University - Science Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

2.60%

发文量

642

审稿时长

49 days

期刊介绍： Journal of King Saud University – Science is an official refereed publication of King Saud University and the publishing services is provided by Elsevier. It publishes peer-reviewed research articles in the fields of physics, astronomy, mathematics, statistics, chemistry, biochemistry, earth sciences, life and environmental sciences on the basis of scientific originality and interdisciplinary interest. It is devoted primarily to research papers but short communications, reviews and book reviews are also included. The editorial board and associated editors, composed of prominent scientists from around the world, are representative of the disciplines covered by the journal.