Recent Applications of Tissue-Engineered 3D Scaffolds in Oncology: Present and Future Perspectives.

IF 2.5 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Protein and Peptide Letters Pub Date : 2026-01-01 DOI:10.2174/0109298665391686251124053211

Devika Tripathi, Vivek Kumar Gupta, Prashant Pandey

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引用次数: 0

Abstract

Three-dimensional (3D) scaffolds are essential in tissue engineering, providing optimal conditions for cellular proliferation, tissue repair, and regeneration. In oncology, these structures are crucial for correctly reproducing the in vivo milieu and effectively modelling the tumor microenvironment (TME). Recent advancements indicate that 3D scaffolds are very effective in preserving cell viability, improving connections between tumors and stroma, and properly replicating cellular communication. Developing sophisticated three-dimensional (3D) cell culture methods that accurately emulate the tumor microenvironment (TME) is essential, given the inherent constraints of traditional two-dimensional (2D) cultures and animal models. These advanced 3D in vitro cancer models provide significant advantages for diagnostic and therapeutic applications, improving our understanding of cancer development and therapy. This article examines the latest advancements in three-dimensional tissue scaffolds for cancer therapy. It discusses the potential impact of such shifts on the field and the types of cancer research and treatments that will be feasible in the future.

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组织工程3D支架在肿瘤学中的最新应用：现在和未来的展望。

三维支架在组织工程中是必不可少的，它为细胞增殖、组织修复和再生提供了最佳条件。在肿瘤学中，这些结构对于正确地再现体内环境和有效地模拟肿瘤微环境（TME）至关重要。最近的进展表明，3D支架在保持细胞活力，改善肿瘤和基质之间的连接以及正确复制细胞通讯方面非常有效。考虑到传统二维（2D）培养和动物模型的固有限制，开发精确模拟肿瘤微环境（TME）的复杂三维（3D）细胞培养方法至关重要。这些先进的3D体外癌症模型为诊断和治疗应用提供了显著的优势，提高了我们对癌症发展和治疗的理解。本文综述了用于肿瘤治疗的三维组织支架的最新进展。它讨论了这种转变对该领域的潜在影响，以及未来可行的癌症研究和治疗类型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Protein and Peptide Letters 生物-生化与分子生物学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

2 months

期刊介绍： Protein & Peptide Letters publishes letters, original research papers, mini-reviews and guest edited issues in all important aspects of protein and peptide research, including structural studies, advances in recombinant expression, function, synthesis, enzymology, immunology, molecular modeling, and drug design. Manuscripts must have a significant element of novelty, timeliness and urgency that merit rapid publication. Reports of crystallization and preliminary structure determination of biologically important proteins are considered only if they include significant new approaches or deal with proteins of immediate importance, and preliminary structure determinations of biologically important proteins. Purely theoretical/review papers should provide new insight into the principles of protein/peptide structure and function. Manuscripts describing computational work should include some experimental data to provide confirmation of the results of calculations. Protein & Peptide Letters focuses on: Structure Studies Advances in Recombinant Expression Drug Design Chemical Synthesis Function Pharmacology Enzymology Conformational Analysis Immunology Biotechnology Protein Engineering Protein Folding Sequencing Molecular Recognition Purification and Analysis