Muhammad Hammad Zaheer, Hamza Zaheer, Zainab Shahnawaz, Muhammad Abdullah, Arslan Tariq
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引用次数: 0
Abstract
Background: Dermatologic infections complicated by sepsis represent a significant yet understudied cause of mortality in the United States, with evolving epidemiological patterns that warrant investigation.
Objective: To examine nationwide trends in sepsis-related mortality due to dermatologic infections from 1999 to 2023, with focus on demographic and geographic disparities.
Methods: This population-based retrospective study analyzed CDC WONDER mortality data using ICD-10 codes for dermatologic infections with sepsis. Joinpoint regression analysis calculated annual percentage changes (APCs) in age-adjusted mortality rates, stratified by gender, age, race/ethnicity, and geographic region.
Results: Among 119,837 deaths, overall mortality showed statistically significant rise during 1999-2004 (APC: 9.05%, p<0.001) and 2012-2023 (APC: 4.72%, p<0.001), with a plateau during 2004-2012. Males showed steeper recent increases (2019-2023: APC: 6.64%, p<0.001) than females. The South region experienced the highest sustained increase (2012-2023: APC: 5.19%, p<0.001). Among racial/ethnic groups, Hispanic populations showed the most pronounced variations, with the highest initial increase followed by a statistically significant decline before rising again.
Limitations: Reliance on death certificate data may introduce coding inconsistencies and underreporting.
Conclusion: Sepsis-related mortality due to dermatologic infections shows concerning upward trends across most demographic groups and regions, highlighting the need for enhanced prevention strategies and targeted interventions for vulnerable populations.
期刊介绍：
The Journal of Public Health Research (JPHR) is an online Open Access, peer-reviewed journal in the field of public health science. The aim of the journal is to stimulate debate and dissemination of knowledge in the public health field in order to improve efficacy, effectiveness and efficiency of public health interventions to improve health outcomes of populations. This aim can only be achieved by adopting a global and multidisciplinary approach. The Journal of Public Health Research publishes contributions from both the “traditional'' disciplines of public health, including hygiene, epidemiology, health education, environmental health, occupational health, health policy, hospital management, health economics, law and ethics as well as from the area of new health care fields including social science, communication science, eHealth and mHealth philosophy, health technology assessment, genetics research implications, population-mental health, gender and disparity issues, global and migration-related themes. In support of this approach, JPHR strongly encourages the use of real multidisciplinary approaches and analyses in the manuscripts submitted to the journal. In addition to Original research, Systematic Review, Meta-analysis, Meta-synthesis and Perspectives and Debate articles, JPHR publishes newsworthy Brief Reports, Letters and Study Protocols related to public health and public health management activities.
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