A liquid engine: How Spef1 droplets set the ciliary beat.

IF 4.3 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Structure Pub Date : 2026-05-07 DOI:10.1016/j.str.2026.03.007

Kishore K Mahalingan

引用次数: 0

Abstract

In this issue of Structure, Ren et al.¹ show that the microtubule-associated protein Spef1 undergoes liquid-liquid phase separation mediated by its uniquely charged coiled-coil domain. These dynamic Spef1 condensates enrich tubulin to drive central-pair microtubule (CP-MT) assembly, providing a long-sought mechanistic explanation for CP-MT assembly and planar ciliary beating.

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液体发动机：Spef1液滴如何设定纤毛温度。

在本期的Structure中，Ren et al.1表明微管相关蛋白Spef1在其独特的带电线圈结构域介导下进行了液-液相分离。这些动态的Spef1凝聚物富集了微管蛋白，驱动中心对微管（CP-MT）组装，为CP-MT组装和平面纤毛跳动提供了长期寻求的机制解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Structure 生物-生化与分子生物学

CiteScore

8.90

自引率

1.80%

发文量

155

审稿时长

3-8 weeks

期刊介绍： Structure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding, and/or design, will also be considered. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single-molecule analysis of biological mechanisms are welcome. In general, the editors encourage submission of experimental structural studies that are enriched by an analysis of structure-activity relationships and will not consider studies that solely report structural information unless the structure or analysis is of exceptional and broad interest. Studies reporting only homology models, de novo models, or molecular dynamics simulations are also discouraged unless the models are informed by or validated by novel experimental data; rationalization of a large body of existing experimental evidence and making testable predictions based on a model or simulation is often not considered sufficient.