Effects of exercise training on bone health in elderly people with type 2 diabetes without osteoporosis: A randomised clinical trial.

IF 7.4 3区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes research and clinical practice Pub Date : 2026-05-06 DOI:10.1016/j.diabres.2026.113303

Stefano Balducci, Jonida Haxhi, Lorenza Mattia, Martina Vitale, Luca Pugliese, Giuseppe Argento, Massimo Sacchetti, Giorgio Orlando, Lucilla Bollanti, Nicolina Di Biase, Giuseppe Lucisano, Antonio Nicolucci, Giuseppe Pugliese

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引用次数: 0

Abstract

Aims: To assess the effects of exercise on non-invasive measures of bone health in elderly individuals with type 2 diabetes without osteoporosis.

Methods: In this randomized clinical trial, 200 elderly individuals with type 2 diabetes without osteoporosis were randomized 1:1 to a two-year, specifically-designed exercise training program (Exercise group) or standard care (Control group). Coprimary outcomes were trabecular bone score (TBS), a surrogate measure of bone quality, and bone mineral density (BMD) at three sites. Secondary outcomes were other bone measures and muscle and physical function parameters.

Results: The coprimary endpoints increased in the Exercise group and decreased in the Control group. Significant between-group differences were observed for TBS (mean, 0.016 [95% confidence interval, 0.011-0.021], p < 0.0001, which disappeared after adjusting for abdominal fat indices), and lumbar spine (0.014 [0.005-0.024], p = 0.004), femoral neck (0.017 [0.006-0.028], p = 0.003), and total hip (0.020 [0.010-0.030], p=<0.0001) BMD. Significant between-group differences were observed also for other bone measures, body composition, muscle strength and quality, physical performance, and cardiorespiratory fitness. There were no between-group differences in adverse events.

Conclusions: A two-year exercise training improved several non-invasive measures of bone health, together with muscle and physical function parameters, potentially reducing fracture risk in people with type 2 diabetes.

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运动训练对老年2型糖尿病无骨质疏松患者骨骼健康的影响：一项随机临床试验

目的：评估运动对无骨质疏松的老年2型糖尿病患者非侵入性骨健康指标的影响。方法：在这项随机临床试验中，200名老年2型糖尿病患者无骨质疏松症，按1:1的比例随机分为2年专门设计的运动训练计划（运动组）和标准治疗（对照组）。主要结果是骨小梁评分（TBS），一种替代测量骨质量的方法，以及三个部位的骨矿物质密度（BMD）。次要结果是其他骨骼测量和肌肉和身体功能参数。结果：运动组的主要终点升高，对照组的主要终点降低。TBS组间差异显著（平均值0.016[95%可信区间，0.011-0.021],p ）。结论：两年的运动训练改善了几项非侵入性骨健康指标，以及肌肉和身体功能参数，可能降低2型糖尿病患者的骨折风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes research and clinical practice 医学-内分泌学与代谢

CiteScore

10.30

自引率

3.90%

发文量

862

审稿时长

32 days

期刊介绍： Diabetes Research and Clinical Practice is an international journal for health-care providers and clinically oriented researchers that publishes high-quality original research articles and expert reviews in diabetes and related areas. The role of the journal is to provide a venue for dissemination of knowledge and discussion of topics related to diabetes clinical research and patient care. Topics of focus include translational science, genetics, immunology, nutrition, psychosocial research, epidemiology, prevention, socio-economic research, complications, new treatments, technologies and therapy.