Variations in Treatment Prescription and Survival Outcomes Between Older and Younger Patients With Mucosal Head and Neck Squamous Cell Carcinoma Treated With Radiotherapy.

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2026-10-01 Epub Date: 2026-05-05 DOI:10.1002/hed.70310

Farhannah Aly, Joseph Descallar, Purnima Sundaresan, Alexis Andrew Miller, Lois Holloway, Shalini Vinod

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引用次数: 0

Abstract

Purpose: To investigate treatment variations and outcomes between older (≥ 70 years) and younger (< 70 years) patients with mucosal head and neck squamous cell carcinoma (mHNSCC) treated with radiotherapy.

Methods: A multicenter retrospective review of patients diagnosed from 2010 to 2018 was conducted. Patient, tumor, and treatment data were collected, including overall survival (OS) and progression-free survival (PFS). Multivariable analyses examined factors influencing standard-of-care (SOC) treatment, OS, and PFS.

Results: Of 1553 patients, 432 patients were ≥ 70 years. Older patients were significantly less likely to receive curative treatment, SOC, or concurrent systemic therapy. Age, marital status, ECOG status, stage, and subsite influenced SOC treatment. Three-year OS and PFS were lower in older patients. ECOG status, stage, subsite, and SOC treatment were significantly associated with OS and PFS. Older age and smoking status were significantly associated with lower OS but not PFS.

Conclusions: Older patients should be offered SOC treatment where appropriate for maximal disease control and survival.

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老年和年轻头颈部粘膜鳞状细胞癌放疗患者治疗处方和生存结果的差异。

目的：探讨老年人（≥70岁）和年轻人之间的治疗差异和结局(方法：对2010年至2018年诊断的患者进行多中心回顾性分析。收集患者、肿瘤和治疗数据，包括总生存期（OS）和无进展生存期（PFS）。多变量分析检查了影响标准护理（SOC）治疗、OS和PFS的因素。结果：1553例患者中，432例患者年龄≥70岁。老年患者接受根治性治疗、SOC或并发全身治疗的可能性显著降低。年龄、婚姻状况、ECOG状态、分期和亚部位影响SOC的治疗。老年患者的3年OS和PFS较低。ECOG状态、分期、亚位点和SOC治疗与OS和PFS显著相关。年龄和吸烟状况与较低的OS显著相关，但与PFS无关。结论：老年患者应在适当的情况下给予SOC治疗，以最大限度地控制病情和提高生存率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.